摘要
“瘦肉精”系一类具有相似结构的β-肾上腺素受体激动剂化合物,曾被滥用作为动物生长促进剂,以提高胴体瘦肉率。中国虽自2010年起禁止其应用于动物养殖环节,但当前,“瘦肉精”类物质非法添加现象仍时有发生,且其替代品多、隐蔽性不断增强对畜产品安全和人类健康仍构成极大威胁。功能纳米材料所具有的特殊结构及性质,极大地提升了现有传感检测技术的性能,使得现有传感检测技术不断朝着灵敏、高效、简便、低成本及抗干扰能力不断增强等方向发展。该文分别从金纳米材料、碳质纳米材料、量子点以及其他新型纳米材料角度出发,总结了以上纳米材料与传感检测技术相结合在“瘦肉精”检测方面的研究进展,分析了各种检测方法的优缺点,并提出了未来功能纳米材料与传感检测技术相结合需要提升的地方,为下一步开发更灵敏准确、简便易行、高通量及低成本的检测方法提供参考。
The “lean meat agents” is a class of β-agonists with a similar structure, which had been abused as an animal growth promoter to improve carcass lean meat rate. However, the drug residue accumulation in meat and body tissues would cause acute poisoning after eating, which gave rise to muscular pain, dizziness, cardiacpalpitation and vomiting, so China has banned its application for growth promotion in animal breeding processes since 2010. But the illegal abuse of “lean meat agents” still frequently occurs in some animal farms. Besides, the plenty of substitutes and increasingly concealing performance still pose a great threat to the safety of animal products and human health. The frequently abused ‘‘lean meat agents’’ include clenbuterol (CLE), ractopamine (RAC), salbutamol (SAL), terbutaline, cimaterol, phenylethanolamine A, etc. At present, various analytical methods have been developed to detect the drug residue, including high performance liquid chromatography (HPLC), gas chromatography mass spectrometry (GC-MS), liquid chromatography mass spectrometry (LC-MS), capillary electrophoresis (CE) and enzyme-linked immunoassay (ELISA), lateral flow chromatography, surface-enhanced Raman immunity, and molecular imprinting polymers, and so on. While these chromatographic methods all require complicated sample pre-treatments, which is not only laborious and time consuming but also sophisticated and large apparatus. Thus, they are most often used as precise quantitative and confirmatory methods, and not fit to the rapid screening. The ELISA and lateral flow chromatography are suitable for field analysis and extensive screening, but the sensitivity is not unsatisfactory in most time. So the routine methods have been unable to meet the requirements of multiple application scenarios and the complex sample substrates. In the past decades, the nanotechnology has made great progress. The functional nanomaterials possess a lot of extraordinary property, such as large surface-to-volume ratio, excellent electric
作者
赵杰
梁刚
李安
满燕
靳欣欣
潘立刚
Zhao Jie;Liang Gang;Li An;Man Yan;Jin Xinxin;Pan Ligang(Beijing Research Center for Agricultural Standards and Testing,Beijing Academy of Agriculture and Forestry Science,Beijing 100097,China;Ministry of Agriculture,Risk Assessment Lab for Agro-products (Beijing),Beijing 100097,China)
出处
《农业工程学报》
EI
CAS
CSCD
北大核心
2019年第18期255-266,共12页
Transactions of the Chinese Society of Agricultural Engineering
基金
北京市农林科学院博士后科研基金(2018-ZZ-020)
北京市农林科学院科技创新能力建设专项(KJCX20170420)
北京市自然科学基金(6194038、L182031)
关键词
传感器
纳米技术
无损检测
功能纳米材料
瘦肉精
sensors
nanotechnology
non destructive inspection
nanomaterials
lean meat agents
