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乙型肝炎病毒前S区缺失突变与肝细胞癌相关性研究进展

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摘要 肝细胞癌是常见恶性肿瘤之一,全球肝细胞癌发病率和病死率逐年上升,严重威胁人们的生命[1-2]。据估计,全世界有超过3.5亿人存在乙型肝炎病毒(HBV)感染,亚洲超过25%的HBV慢性感染患者死于其相关疾病。在我国,大多数肝细胞癌继发于慢性乙型病毒性肝炎,早期症状不明显,常于晚期发现,恶性程度高,而且尚无有效治疗措施。HBV是一种小型的包膜DNA病毒,可导致急性和慢性感染性疾病[3]。大多数HBV急性感染具有自限性,但慢性感染可导致肝细胞癌[4]。
作者 邵宇 郭进军
出处 《现代医药卫生》 2019年第20期3164-3166,共3页 Journal of Modern Medicine & Health
基金 重庆市科技局基础研究与前沿探索项目(cstc2018jcyjAX0006)
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