摘要
目的探讨特布他林联合羧甲司坦片治疗哮喘急性发作的临床疗效及对血清白细胞介素-33(IL-33)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)的影响。方法选取2015年1月至2018年1月安徽医科大学附属安庆医院收治的80例哮喘急性发作期患者作为研究对象,依据治疗方法不同分为对照组(n=39)和观察组(n=41)。对照组采用羧甲司坦片治疗,0.5 g口服,每日3次;观察组在对照组治疗的基础上加用特布他林,将2.5 mg特布他林加入3~4 m L 0.9%氯化钠注射液雾化吸入,每日2次,两组患者均治疗7 d。比较两组患者治疗后的临床疗效,治疗前后的血清IL-33、CRP、TNF-α、第1秒用力呼气量(FEV1)占预计值百分比、用力肺活量(FVC)、FEV1/FVC水平及不良反应发生情况。结果观察组总有效率高于对照组[95.12%(39/41)比71.79%(28/39)](P<0.05)。治疗后,两组患者血清IL-33、CRP、TNF-α水平均低于治疗前,观察组患者血清IL-33、CRP、TNF-α水平均低于对照组(P<0.05);治疗后两组患者FEV1占预计值百分比、FVC、FEV1/FVC水平均高于治疗前(P<0.05),且观察组各肺功能指标均明显高于对照组(P<0.05)。观察组总不良反应发生率低于对照组[7.32%(3/41)比30.77%(12/39)](P<0.05)。结论特布他林联合羧甲司坦片治疗哮喘急性发作期患者的效果显著,可显著降低哮喘急性发作期患者血清IL-33、CRP、TNF-α水平。
Objective To investigate the clinical efficacy of terbutaline combined with carbocisteine? tablet in the treatment of acute asthma attack and its effects on serum interleukin-33(IL-33),C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α).Methods A total of 80 patients with acute attack of asthma admitted to Anqing Municipal Hospital Affiliated to Anhui Medical University from Jan.2015 to Jan.2018 were included in the study.They were divided into a control group(n = 39) and an observation group(n = 41) according to the treatment method.The control group was treated with carbocisteine tablets,0.5 g/time orally,3 times per day;the observation group was treated with terbutaline combined with carbocisteine tablets(same as the control group): 2.5 mg terbutaline added into 3-4 m L 0.9% sodium chloride injection for atomized inhalation,twice a day,both groups were treated for 7 days.The curative effect,serum IL-33,CRP,TNF-α,first second forced expiratory volume(FEV1) percentage of the predicted value,forced vital capacity(FVC),FEV1/FVC levels and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[95.12%(39/41) vs 71.79%(28/39)](P<0.05).After treatment,the serum levels of IL-33,CRP and TNF-α in the two groups were significantly lower than before treatment,and the serum levels of IL-33,CRP and TNF-α in the observation group were lower than those in the control group(P<0.05).After treatment,FEV1 percentage of the predicted value,FVC,FEV1/FVC levels were significantly higher than before treatment(P<0.05),and the improvement of pulmonary function index in the observation group was significantly higher than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group[7.32%(3/41) vs 30.77%(12/39)](P<0.05).Conclusion Terbutaline combined with carbocisteine tablet can significantly reduce the levels of serum IL-33,CRP and TN
作者
刘静
施炜
孙泽丽
LIU Jing;SHI Wei;SUN Zeli(Department of Respiratory Medicine,Anqing Municipal Hospital Affiliated to Anhui Medical University,Anqing 246003,China)
出处
《医学综述》
2019年第19期3939-3943,共5页
Medical Recapitulate
