摘要
目的探讨自拟温胃散寒汤治疗脾胃虚寒型慢性萎缩性胃炎(CAG)的临床效果。方法选取2016年3月~2018年8月青海省交通医院收治的脾胃虚寒型CAG患者103例,根据随机数字表法将患者分为对照组(n=51)和研究组(n=52),对照组给予七味胃痛胶囊治疗,研究组在对照组基础上联合自拟温胃散寒汤治疗,比较两组患者临床效果、临床症状积分、血浆血栓烷B2(TXB2)、胃蛋白酶原(PG)水平,记录两组治疗期间不良反应发生情况。结果研究组治疗8周后临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组治疗8周后口干口苦、上腹饱胀、乏力、纳差、消化不良等临床症状积分均较治疗前降低,且研究组低于对照组(P<0.05)。两组治疗8周后血浆TXB2水平较治疗前降低,且研究组低于对照组(P<0.05);两组治疗8周后血浆PGⅠ水平较治疗前升高,且研究组高于对照组(P<0.05);两组治疗前及治疗8周后血浆PGⅡ水平组间和组内比较差异无统计学意义(P>0.05)。两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论自拟温胃散寒汤治疗脾胃虚寒型CAG的效果显著,可有效改善患者的临床症状,改善机体血浆TXB2、PG水平,且不增加不良反应发生率,临床应用价值较高。
Objective To explore clinical effect of self-made Wenwei Sanhan Decoction in the treatment of chronic atrophic gastritis (CAG) with spleen-stomach deficiency and cold type. Methods One hundred and three CAG patients with spleen-stomach deficiency and cold type admitted to Qinghai Transportation Hospital from March 2016 to August 2018 were selected, they were divided into control group (n = 51) and study group (n = 52) according to the random number table method. Control group was treated with Qiwei Weitong Capsules and study group was treated with Wenwei Sanhan Decoction on the basis of control group. Clinical effect, clinical symptom score and thromboxane B2 (TXB2), pepsinogen (PG) were compared between two groups. Incidence of adverse reactions during the treatment in two groups was observed. Results After treatment of 8 weeks, total effective rate of study group was significantly higher than that of control group, there was a significant difference (P<0.05). After treatment of 8 weeks, scores of clinical symptoms such as dry mouth and bitter mouth, fullness of upper abdomen, fatigue, poor appetite, dyspepsia in both groups were lower than those before treatment, and those in study group were lower than those in control group (P<0.05). After treatment of 8 weeks, plasma TXB2 level of two groups was lower than that before treatment, and level of TXB2 in study group was lower than that in control group (P<0.05). After treatment of 8 weeks, level of plasma PGⅠ in two groups was higher than that before treatment, and that in study group was higher than that in control group (P<0.05). There was no significant difference in plasma PGⅡ level between two groups before treatment and after treatment of 8 weeks (P>0.05). There was no significant difference in incidence rate of adverse reaction between two groups during treatment (P>0.05). Conclusion Self-made Wenwei Sanhan Decoction is effective in the treatment of CAG with spleen-stomach deficiency and cold type. It can effectively improve clinical symptoms of patien
作者
马润兴
马玉寿
MA Runxing;MA Yushou(Department of Traditional Chinese Medicine,Qinghai Transportation Hospital,Qinghai Province,Xi′ning 810001,China;Department of Traditional Chinese Medicine,the First People′s Hospital of Huangzhong County of Qinghai Province,Qinghai Province,Huangzhong 810000,China)
出处
《中国医药导报》
CAS
2019年第25期118-121,共4页
China Medical Herald
基金
青海省科技计划项目(2015-ZJ-772)
关键词
自拟温胃散寒汤
脾胃虚寒型
慢性萎缩性胃炎
血栓烷B2
胃蛋白酶原
Self-made Wenwei Sanhan Decoction
Spleen-stomach deficiency and cold type
Chronic atrophic gastritis
Thromboxane B2
Pepsinogen
