摘要
目的探讨血清血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)水平与慢性阻塞性肺疾病(COPD)患者肺动脉高压(PAH)的关系。方法选取2015年6月~2018年12月上海交通大学附属第六人民医院(以下简称“我院”)收治的COPD患者,共143例。根据PAH诊断标准将患者分为对照组A(COPD未并发PAH)61例和观察组(COPD并发PAH)82例。另选取同期来我院健康体检的40名肺功能正常者作为对照组B。根据COPD患者病情严重程度分为急性期(69例)、缓解期(49例)、稳定期(25例)。根据肺动脉收缩压(PASP)升高程度将观察组分为轻度PAH组(32例)、中度PAH组(27例)、重度PAH组(23例)。结果对照组A、观察组血清bFGF、VEGF水平与PASP均显著高于对照组B,观察组明显高于对照组A,差异有统计学意义(P <0.05)。COPD患者急性期、缓解期血清VEGF、bFGF水平与PASP均显著高于稳定期,急性期明显高于缓解期,差异有统计学意义(P <0.05)。中度PAH组、重度PAH组血清VEGF、bFGF水平均显著低于轻度PAH组,重度PAH组明显低于中度PAH组,差异有统计学意义(P <0.05)。COPD未并发PAH患者血清VEGF、bFGF水平与PASP呈正相关(r=0.346、0.438,P=0.011、0.006)。COPD并发PAH患者血清VEGF、bFGF水平与PASP呈负相关(r=-0.421、-0.339,P=0.008、0.012)。结论 COPD患者中血清VEGF、bFGF水平存在异常表达,其表达水平与PASP存在密切联系。
Objective To investigate the relationship between serum levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and pulmonary hypertension (PAH) in patients with chronic obstructive pulmonary disease (COPD). Methods One hundred and forty-three COPD patients admitted to Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University (“our hospital” for short) from June 2015 to December 2018 were selected. According to the diagnostic criteria of PAH, the patients were divided into control group A (COPD without PAH) in 61 cases and observation group (COPD with PAH) in 82 cases. In addition, 40 people with normal lung function who were taken physical examination in our hospital for the same period were selected as the control group B. According to the severity of the condition, the patients with COPD were divided into acute stage (69 cases), remission stage (49 cases), stable stage (25 cases). The observation group was divided into mild PAH group (32 cases), moderate PAH group (27 cases) and severe PAH group (23 cases) according to the degree of increase of pulmonary systolic pressure (PASP). Results The levels of serum VEGF, bFGF and PASP in control group A and observation group were significantly higher than those in control group B, while those in observation group were significantly higher than those in control group A, and the differences were statistically significant (P < 0.05). The levels of VEGF and bFGF in COPD patients in acute stage and remission stage were significantly higher than those in stable stage, while the levels in acute stage were significantly higher than those in remission stage, and the differences were statistically significant (P < 0.05). Serum levels of VEGF and bFGF in moderate PAH group and severe PAH group were significantly lower than those in mild PAH group, while those in severe PAH group were significantly lower than those in moderate PAH group, and the differences were statistically significant (P < 0.05). Serum levels of VEGF
作者
沈慧
费晓云
顾晓花
SHEN Hui;FEI Xiaoyun;GU Xiaohua(Department of Respiratory Medicine,Shanghai Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)
出处
《中国医药导报》
CAS
2019年第26期125-128,共4页
China Medical Herald
基金
上海市卫生和计划生育委员会科研课题（20164056）
关键词
血管内皮生长因子
碱性成纤维细胞生长因子
慢性阻塞性肺疾病
肺动脉高压
相关性
Vascular endothelial growth factor
Basic fibroblast growth factor
Chronic obstructive pulmonary disease
Pulmonary hypertension
Correlation
