摘要
目的研究浅表性膀胱癌患者实施等离子电切术后二次电切对预后的影响情况。方法选择我院收治的浅表性膀胱癌患者52例,随机分为观察组和对照组各26例,其中对照组实施等离子电切术,观察组在首次电切术后4周实施二次电切。观察术后1月观察并发症发生率,术后实施为期1年随访,观察肿瘤复发情况[复发例数(原发部位、新生部位)、不同级别复发情况、复发平均月份],记录末次随访尿液中肿瘤标志物水平[膀胱肿瘤抗原(Bladder tumorantigen,BTA)、核基蛋白22(Nuclear matrix protein 22,NMP22)]。结果两组术后1月内并发症发生率相当(P>0.05)。观察组术后1年肿瘤复发率为23.08%,低于对照组57.69%(P<0.05);观察组术后1年肿瘤平均复发时间高于对照组(P<0.05);观察组高级别肿瘤(G2+G3)复发率19.05%,低于对照组63.16%(P<0.05)。观察组末次随访BTA、NMP22水平均明显低于对照组(P<0.05)。结论等离子电切术后二次电切能降低浅表性膀胱癌患者癌症复发率,延长复发时间,且对高级别膀胱癌复发率降低较明显,还可降低尿液中肿瘤标志物水平。
Objective To study the effects of secondary electric resection after plasmakinetic resection on the prognosis of patients with superficial bladder cancer.Methods A total of 52 patients with superficial bladder cancer admitted to our hospital were selected and randomly divided into observation group and control group,with 26 cases in each group.Control group was treated with plasmakinetic resection,and observation group was given secondary electric resection at 4 w after first electric resection.The incidence rate of complications was observed at 1 month after operation.The patients were followed up for 1 year after operation,and the tumor recurrence situation[recurrence number(primary site,new site),recurrence of different grades,average recurrence month]was observed,and the levels of urine tumor markers[bladder tumor antigen(BTA),nuclear matrix protein 22(NMP22)]were recorded at the last follow-up.Results The incidence rate of complications was comparable within 1 month after operation in the two groups(P>0.05).The tumor recurrence rate at 1 year after operation in observation group was lower than that in control group(23.08%vs 57.69%)(P<0.05).The average tumor recurrence time in observation group at 1 year after operation was higher than that in control group(P<0.05).The recurrence rate of high-grade tumor(G2+G3)was lower than that in control group(19.05%vs 63.16%)(P<0.05).The levels of BTA and NMP22 in observation group at the last follow-up were significantly lower than those in control group(P<0.05).Conclusion Secondary electric resection after plasmakinetic resection can reduce the cancer recurrence rate and prolong the recurrence time in patients with superficial bladder cancer,and significantly reduce the recurrence rate of high-grade bladder cancer,and lower the levels of urine tumor markers.
作者
冯广寿
周雄
FENG Guang-shou;ZHOU Xiong(Maoming Dianbai District People’s Hospital,Maoming 525400,Guangdong Province,China)
出处
《罕少疾病杂志》
2019年第5期59-62,共4页
Journal of Rare and Uncommon Diseases
关键词
等离子双极电切
浅表性膀胱癌
二次电切
复发
Plasmakinetic Resection
Superficial Bladder Cancer
Secondary Electric Resection
Recurrence
