摘要
目的探讨神经导航辅助显微镜下经鼻蝶入路垂体瘤切除术的临床疗效评价。方法收集2014年10月-2018年10月在我院行显微镜下经鼻蝶入路手术切除的50例垂体瘤患者的临床资料。按照手术方案不同分为观察组和对照组各25例。观察组患者接受神经导航辅助显微镜下经鼻蝶入路垂体瘤切除术,对照组患者接受显微镜下经鼻蝶入路垂体瘤切除术。比较两组患者手术情况及术后住院情况(包括手术时间、术中出血量及术后住院时间)、肿瘤全切率、手术前后血清内分泌指标变化情况(包括GH、PRL水平)、术后并发症情况(即术后并发症发生率)。结果观察组患者手术时间、术中出血量及术后住院时间均低于对照组,差异有统计学意义(P<0.05);观察组患者肿瘤全切率略高于对照组,但两组间肿瘤全切率差异无统计学意义(P>0.05);观察组患者术后血清生长激素(GH)、催乳素(PRL)水平均略低于对照组,但两组间手术前后血清内分泌指标变化情况差异无统计学意义(P>0.05);两组患者术后并发症发生率差异无统计学意义。结论神经导航辅助显微镜下经鼻蝶入路垂体瘤切除术治疗垂体瘤疗效优于单纯显微镜下经鼻蝶入路垂体瘤切除术,手术时间短、术中出血少、术后恢复快,同时不增加并发症的发生,值得临床推荐。
Objective To investigate the effect of resection for pituitary tumors through transsphenoidal approach with microscopic neuronavigation assisted. Methods From October 2014 to October 2018, 25 patients with pituitary tumor were operated in our hospital with neuronavigation, which were set as the observation group. Meanwhile, 25 patients with pituitary tumor underwent surgical treating through transsphenoidal approach without neuronavigation were set as the control group. SPSS 20.0 were used for statistical analysis to compare the differences between the two groups, including the operation time, blood loss, hospitalization time after operation, total tumor removal rate, hormone level, and complications of the two groups. Results The operation time, blood loss and hospitalization after operation time of the observation group were less than that of the control group, and there was statistical significance ( P <0.05). The total tumor removal rate of the observation group was a little more than that of the control group, but there was no statistical significance ( P >0.05). The level of growth hormone (GH) and prolactin (PRL) of the observation group were a little less than that of the control group, but there was no statistical significance ( P >0.05). And there was no statistical significance between the incidence rate of postoperative complications of the two groups. Conclusion The effect of resection for pituitary tumors through transsphenoidal approach with microscopic neuronavigation assisted is significant, which can shorten the course, reduce the blood loss, quicken recovery of a patient from operation, not increase the incidence rate of postoperative complications, and it is worthy to be recommended to clinical application.
作者
黄朝阳
卢恒聪
曹志恺
HUANG Chaoyang;LU Hengcong;CAO Zhikai(Department of Neurosurgery, Guangzhou First People s Hospital, Guangzhou 510180, China)
出处
《广州医药》
2019年第5期41-44,共4页
Guangzhou Medical Journal
关键词
垂体瘤
显微手术
神经导航
Pituitary tumor
Neuronavigation
Microscopy
