摘要
梅毒是一种多阶段发展的性传播疾病,临床表现复杂,实验室诊断主要依赖血清学方法。近十余年来,基于重组梅毒螺旋体(Tp)诊断抗原的血清学方法大力促进了梅毒特异性实验室诊断的快速发展。但目前所采用的重组抗原对诊断早/晚期梅毒,或区分不同感染阶段,或疗效判断仍然存在不足。本文综述重组Tp脂蛋白及新型候选抗原(包括膜表面暴露蛋白、黏附蛋白、周质间隙蛋白和鞭毛蛋白等)在梅毒诊断中的应用价值及局限性,并概括了最佳候选Tp诊断抗原组的条件,为进一步研究其他Tp诊断抗原提供参考。
Syphilis is a multistage sexually transmitted disease with complicated clinical manifestations,and serological studies remain the main method for laboratory diagnostics of syphilis.In recent ten years,serological methods,based on recombinant antigens of Treponema pallidum,considerably promoted the rapid development of treponema-specifc laboratory diagnostics of syphilis infection.However,current recombinant antigens are still inadequate for the diagnosis of early or late syphilis and for distinguishing syphilis stages or for the assessment of therapeutic efficacy.This article reviews the application value and limitations in the diagnosis of syphilis of recombinant T.pallidum lipoproteins and novel antigens including surface-exposed proteins,adhesins,and periplasmic and flagellar proteins.and summarizes the criteria for selection of optimal antigens panel,which may provide a reference for further study of other novel diagnostic antigens of T.pallidum.
作者
王斯倩
符波
赵宇龙
廖梦佳
李长清
曹龙古
曾铁兵
WANG Si-qian;FU Bo;ZHAO Yu-long;LIAO Meng-jia;LI Chang-qing;CAO Long-gu;ZENG Tie-bing(Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province,University of South China,Hengyang 421001,China;Clinical laboratory of the First Pepole’s Hospital of Changde City,Changde 415003,China;Undergraduate of Grade 2016,Clinical medicine Speciality,Hengyang Medical College,University of South China,Hengyang 421001,China;Nanyue Biopharmaceutical Co.,Ltd.,Hengyang 421002,China;College of Medical Imaging and lnspection,Xiangnan University,Chenzhou 423000,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2019年第9期837-842,共6页
Chinese Journal of Zoonoses
基金
国家自然科学基金（No.81273322）
湖南省分子靶标新药研究协同创新中心项目（湘教通[2014]405号）
湖南省教育厅资助科研项目（No.17B245）
湖南省研究生培养创新基地项目（湘教通[2017]451号）
湖南省研究生科研创新项目（No.CX2018B618）
南华大学大学生科研创新项目（No.2018XJXZ139）联合资助~~
关键词
梅毒螺旋体
重组抗原
血清学诊断
综述
Treponema pallidum
recombinant antigen
serological diagnosis
review
