摘要
Summary of main observation and conclusion Described herein is an organocatalytic enantioselective protonation of monofluorinated silyl enol ethers,affording an array of optically active α-secondary α-fluoroketones in good to high yields and enantioselectivities,under the catalysis of bifunctional cinchonidine derived squaramide C4.It represents a rare example of facile synthesis of enantioenriched α-secondary α-fluoroketones.With D20 as the deuterium source and MeOD as the solvent,the first highly enantioselective preparation of chiral α-deuterated α-fluoroketones in >92% deuteration is developed.
基金
support from the National Natural Science Foundation of China (No.21725203).
