摘要
目的目前国内外对于颈动脉斑块稳定性与左心室结构功能的研究鲜有报道。文中探讨左心室功能对颈动脉粥样硬化斑块稳定性的影响。方法选取2017年6月10日至2019年1月8日江苏省中医院神经内科收治的90例颈动脉粥样硬化患者(颈动脉内膜中层厚度>0.2cm),并通过超声造影(CEUS)分级确定斑块的稳定性。根据CEUS结果将患者分成斑块稳定组和不稳定组,比较2组患者一般临床资料、相关生化指标以及左心室结构功能指标的差异,通过logistic多因素回归分析检验左心室结构功能对斑块稳定性的影响。结果单因素分析结果显示,E峰(χ^2=2.170,P=0.034)、室隔舒张末厚度(χ^2=-1.972,P=0.049)、糖尿病史(χ^2=10.102,P=0.001)是斑块稳定性的危险因素。多因素分析结果显示,E峰(OR=0.022,P=0.014)、糖尿病史(OR=0.185,P=0.002)是斑块稳定性的独立影响因素。结论左心室功能与斑块稳定性存在独立相关性。心室结构功能的改变可预测斑块稳定性。
Objective At present,there are few reports on the stability of carotid plaque and left ventricular function at home and abroad. The article investigated the factors influencing the stability of left ventricular function on carotid atherosclerotic plaque. Methods 90 patients with carotid atherosclerosis(carotid intima-media thickness >0.2 cm)admitted in the Department of Neurology, Jiangsu Provincial Hospital of Traditional Chinese Medicine from June 10,2017 to January 8,2019 were selected and their stability of plaques was graded by contrast-enhanced ultrasound(CEUS). The patients were divided into two groups according to the stability of plaque. The differences of general clinical data,related biochemical indexes and left ventricular function indexes between the two groups were compared. The effects of left ventricular structural function on plaque stability were examined by logistic multivariate regression analysis. Results Univariate analysis showed that E peak(χ^2=2.170,P=0.034),ventricular septal thickness(χ^2=-1.972,P= 0.049),diabetes history(χ^2=10.102,P=0.001)were the risk factors of plaque stability and the differences were statistically significant (P < 0.05). Multivariate analysis showed that E peak(OR=0.022,P=0.014)and diabetes history(OR=0.185,P=0.002)were indepen? Dent influencing factors of plaque stability. Conclusion There is an independent correlation between left ventricular function and plaque stability,and plaque stability can predict changes in ventricu? Lar structural function.
作者
周婷婷
李辉
姜亚军
陈兆耀
王雨轩
ZHOU Ting-ting;LI Hui;JIANG Ya-jun;CHEN Zhao-yao;WANG Yu-xuan(Department of Neurology,Jiangsu Province Hospital of Chinese Medicine,Affiliated Hospital of Nanjing Universityof Chinese Medicine,Nanjing 210021,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第9期954-957,共4页
Journal of Medical Postgraduates
基金
江苏省社会发展面上项目(BE2016808)
关键词
左心室功能
颈动脉粥样硬化
斑块稳定性
超声造影
left ventricular function
carotid atherosclerosis
plaque stability
carotid contrast-enhanced ultrasound
