摘要
目的探讨丁苯酞注射液与瑞舒伐他汀钙片联合治疗急性进展性脑梗死患者的临床效果及对超敏C反应蛋白(hs-CRP)及神经功能指标的影响。方法将本院诊治的急性进展性脑梗死120例按照随机数表法分2组。对照组给予瑞舒伐他汀治疗,研究组予以丁苯酞注射液与瑞舒伐他汀联合治疗。分析2组临床效果、hs-CRP水平、美国国立卫生研究院卒中量表(NIHSS)评分、简易智能相关精神状态量表(MMSR)评分、肿瘤坏死因子-α(TNF-α)及同型半胱氨酸(Hcy)、低密度的脂蛋白胆固醇(LDL-C)。结果治疗后,研究组总有效率显著高于对照组,差异有统计学意义(P<0.05);研究组NIHSS评分显著低于对照组,MMSR评分显著高于对照组,且研究组Hcy、hs-CRP、TNF-α及LDL-C水平均显著低于对照组,差异有统计学意义(P<0.05)。结论急性进展性脑梗死患者应用丁苯酞注射液与瑞舒伐他汀联合治疗能够提高临床效果,改善患者神经及认知功能,降低Hcy、hs-CRP、TNF-a及LDL-C水平。
Objective To evaluate the efficacy of butylphthalide injection combined with rosuvastatin calcium tablets for patients with acute progressive cerebral infarction and its impact on high sensitivity C reactive protein (hs-CRP) and neurological function.Methods A total of 120 patients with acute progressive cerebral infarction were divided into two groups according to random number table method.The control group was given rosuvastatin calcium tablets,while the study group received butylphthalide injection and rosuvastatin calcium tablets.Clinical effects,hs-CRP level,National Institutes of Health Stroke Scale(NIHSS)score,modified mental state scale(MMSR)score,homocysteine(Hcy),tumor necrosis factor-α(TNF-α),low density lipoprotein cholesterol(LDL-C).Results After treatment,the total effective rate of the study group was higher than that of the control group( P <0.05).The NIHSS score of the study group was lower,and MMSR score was higher than that of the control group,and Hcy,hs-CRP,TNF-α and LDL-C levels in the study group were lower than that of the control group( P <0.05).Conclusion Butylphthalide injection combined with rosuvastatin for patients with acute progressive cerebral infarction can improve clinical outcomes,improve neurological and cognitive function,reduce Hcy,hs-CRP,TNF-α and LDL-C levels.
作者
宋瑾
SONG Jin(Baoji Second People′s Hospital,Baoji,Shaanxi,721000)
出处
《实用临床医药杂志》
CAS
2019年第17期45-47,51,共4页
Journal of Clinical Medicine in Practice
关键词
急性进展性脑梗死
瑞舒伐他汀
丁苯酞注射液
超敏C反应蛋白
神经功能
acute progressive cerebral infarction
rosuvastatin
butylphthalide injection
high sensitivity C reactive protein
neurological function
