摘要
神经管缺陷(Neural tube defects,NTDs)是由于胚胎发育期神经管闭合不全导致的出生缺陷,是新生儿出生缺陷高发疾病之一。目前已知,针对孕前和孕早期妇女补充叶酸能够降低NTDs的发生率。最新研究表明糖尿病妊娠等其他因素同样能够作用于孕妇,导致胎儿发生NTDs。本文回顾关于糖尿病妊娠诱导新生儿NTDs发生机制的相关文献,为预防NTDs提供新的研究方向。
Neural tube defects are one of the most common types of neonatal birth defects caused by incomplete neural tube closure during embryonic development.It is currently well-known that supplementing folic acid in women before and during pregnancy can reduce the incidence of neural tube defects.The latest researches show that there are still other factors affecting pregnant women,such as diabetes pregnancy,leading to neural tube defects,This article reviews the relevant literature on neonatal neural tube defects induced by diabetic pregnancy and providing new dimensions for preventing neural tube defects.
作者
邹倩倩(综述)
蔡春泉(审校)
Zou Qianqian;Cai Chunquan(Graduate School,Tianjin Medical University,Tianjin 300070,China;Department of Neurosurgery,Municipal Children's Hospital,Tianjin 300134,China)
出处
《临床小儿外科杂志》
CAS
2019年第9期789-794,共6页
Journal of Clinical Pediatric Surgery
基金
国家自然科学基金(编号:81771589)
天津市重大疾病防治科技重大专项(编号:18ZXDBSY00170)
天津市卫生行业重点攻关项目(编号:16KG166)
