摘要
目的探讨培门冬酶(PEG-ASP)和左旋门冬酰胺酶(L-ASP)治疗儿童急性淋巴细胞白血病(ALL)的临床效果。方法收集2018年1月至2019年1月某院收治的89例ALL患儿作为研究对象,随机数表法分为试验组45例和对照组44例。试验组患儿采用含培门冬酶的方案进行化疗,对照组患儿则给予含左旋门冬酰胺酶的方案进行化疗。比较两组患儿治疗的临床效果,不良反应发生率以及用药次数和住院时间等指标。结果试验组和对照组总有效率分别为95.56%、93.18%,组间比较,差异无统计学意义(P>0.05);两组患儿在化疗期间的不良反应多在Ⅰ~Ⅱ级,各项常见不良反应情况经临床比较,差异无统计学意义(P>0.05)。试验组患儿用药次数和住院时间均低于对照组,差异有统计学意义(P<0.05)。结论培门冬酶和左旋门冬酰胺酶用于治疗儿童ALL均有较高的临床效果,且不良反应方面相近,不过培门冬酶作用时间长,给药次数少,临床应用更为方便。
Objective To investigate the clinical effects of permenthase and L-asparaginase in the treatment of acute lymphoblastic leukemia(ALL) in children.Methods 89 cases of ALL children admitted to a hospital from January 2018 to January 2019 were selected as research subjects and randomly divided into the experimental group (45 cases) and the control group(44 cases) by random number table method.The children in the experimental group received chemotherapy with permenthase while the children in the control group received chemotherapy with L-asparaginase.The clinical effect,incidence of adverse reactions,frequency of medication and length of stay in hospital of the two groups were compared.Results The total effective rate of the experimental group and the control group was 95.56% and 93.18% respectively,with no statistical difference between groups(P>0.05).The adverse reactions of the two groups of children during chemotherapy were betweenⅠ~Ⅱlevels.There was no statistical difference between common adverse reactions between the two groups(P>0.05).The frequency of medication and length of stay in hospital of the experimental group were lower than those of the control group,with statistically significant differences(P<0.05).Conclusion Both permenthase and L-asparaginase have high clinical effects in the treatment of ALL in children with similar adverse reactions.However,the effect of permenthase is lasting and the frequency of medication is low with more convenient clinical application.
作者
李风
周鹏
Li Feng;Zhou Peng
出处
《中国疗养医学》
2019年第10期1028-1030,共3页
Chinese Journal of Convalescent Medicine
