摘要
目的研究盐酸丁螺环酮大鼠在体肠吸收及其吸收动力学特征。方法采用大鼠在体肠灌流法,以高效液相色谱(HPLC)法测定循环灌流液中盐酸丁螺环酮的浓度,考察不同肠段、不同药物浓度、不同介质pH值条件下盐酸丁螺环酮的肠道吸收情况,并测定其吸收动力学参数。结果盐酸丁螺环酮在大鼠各肠段的吸收速率大小为十二指肠>空肠>回肠>结肠,吸收速率常数分别为(0.164±0.012),(0.146±0.017),(0.094±0.014),(0.070±0.008) h^-1;在不同浓度和不同pH值条件下,盐酸丁螺环酮的肠道吸收参数间差异无统计学意义。结论盐酸丁螺环酮大鼠在体肠道吸收符合表观一级动力学过程,吸收以被动扩散为主;其在大鼠肠道内吸收不受药物浓度和pH值的影响;在整个肠段均有一定程度的吸收。
Objective To study intestinal absorption and absorption kinetics of buprespirone hydrochloride in rats. Methods Intestinal absorption of buspirone hydrochloride in rats was investigated under different intestinal segments, different drug concentrations and different pH values of media.High performance liquid chromatography(HPLC) was used to determine the concentration of buspirone hydrochloride in circulating irrigation solution and its absorption kinetic parameters. Results The order of absorption rate of buspirone hydrochloride in each intestinal segments of the rats was duodenum > jejunum > ileum > colon.The absorption rate constants were(0.164±0.012),(0.146±0.017),(0.094±0.014),(0.070±0.008) h^-1, respectively;There was no statistically significant difference in intestinal absorption parameters of buspirone hydrochloride at different concentrations and pH values.and there was no statistically significant difference difference between intestinal absorption rate constant of buspirone hydrochloride at different concentrations and pH conditions. Conclusion The absorption of buspirone hydrochloride in the intestine of rats complies with first-order kinetics process, and the absorption was dominated by passive diffusion.Its absorption in the intestine of rats is not affected by the concentration and pH.Buspirone hydrochloride can be absorbed throughout the intestine.
作者
王柯玉
牟雄军
林宁
WANG Keyu;MOU Xiongjun;LIN Ning(College of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China)
出处
《医药导报》
CAS
北大核心
2019年第10期1287-1290,共4页
Herald of Medicine
基金
湖北省教育厅科学技术研究项目(D20101801)
关键词
丁螺环酮
盐酸
吸收动力学
肠道吸收
色谱法
高效液相
Buspirone,hydrochloride
Absorption kinetics
Intestinal absorption
Chromatography,high performance liquid
