摘要
目的探讨甲状腺相关眼病患者外周血中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)、血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)与甲状腺相关眼病的关系。方法选取2017年1月至2018年1月重庆医科大学附属永川医院收治的甲状腺相关眼病患者186例,并将其设为病例组,将同期体检健康人群236例设为对照组。病例组进行病情活动性评分(clinical activity score,CAS),并分为活动组105例,非活动组81例。病例组及对照组均空腹抽静脉血做血常规检查,病例组同时行甲状腺功能检查,根据血常规结果计算NLR及PLR比值,比较病例组与对照组间NLR及PLR的差异,分析病例组NLR、PLR与三碘甲状腺原氨酸(triiodothyronine,T3)、四碘甲状腺原氨酸(tetraiodothyronine,T4)、促甲状腺激素(thyroid stimulating hormone,TSH)间的相关性。结果病例组NLR、PLR明显高于对照组(P<0.05),病例组中活动组患者NLR及PLR高于非活动组(P<0.05),NLR与T4呈负相关(r=-0.168,P=0.02)。结论甲状腺相关眼病患者外周血NLR、PLR较对照升高,且升高程度与病情活动性有关。
Objective To explore the relationship of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)with thyroid-associated ophthalmopathy.Methods From January 2017 to January 2018,186 patients with thyroid-associated ophthalmopathy and 236 healthy controls were enrolled in the study.Fasting blood samples were collected and analyzed for venous blood routine examination.The patients were examined for thyroid function at the same time.NLR and PLR values were calculated in consequence of complete blood count results obtained from the study and control groups.We compared the differences of NLR and PLR between case and control group.The correlation between NLR,PLR and T3,T4,TSH in case group were analyzed.Results The NLR and PLR were significantly higher in patients than the control subjects(P<0.05).NLR and PLR in the active TAO group was significantly higher than that in the inactive TAO group(P<0.05),and NLR was negatively correlated with T44(r=-0.168,P=0.02).Conclusion NLR and PLR were elevated in patients with thyroid associated ophthalmopathy,and were related to disease activity.
作者
张灵丽
宋胜仿
刘世纯
邬羽飞
张永烨
李华
ZHANG Ling-li;SONG Sheng-fang;LIU Shi-chun;WU Yu-fei;ZHANG Yong-ye;LI Hua(Department of Ophthalmology, Yongchuan Hospital of Chongqing University, Chongqing 402160,China)
出处
《中国临床医生杂志》
2019年第10期1165-1167,共3页
Chinese Journal For Clinicians
基金
重庆市卫生局医学科研计划项目(2013-2-073)
重庆医科大学附属永川医院科研项目(YTLCX201626)
重庆医科大学附属永川医院科研项目(YJZQN201530)
