摘要
目的 探讨左氧氟沙星联合肝素对血液透析导管感染患者血清PCT、CRP水平的影响。方法 选取2017年1月至2018年1月本院收治的82例血液透析导管感染患者,随机分为两组,各41例。对照组应用左氧氟沙星治疗,研究组在对照组基础上应用肝素治疗。比较两组患者不良反应发生率、WBC与CRP水平、PCT与ESR水平、炎性因子水平。结果 两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗前,两组患者WBC、CRP水平比较,差异均无统计学意义(均P>0.05);治疗后,研究组WBC、CRP水平分别为(4.1±2.2)×10^9/L、(5.1±2.3)mg/L,均低于对照组,差异均有统计学意义(均P<0.05);治疗前,两组患者PCT、ESR水平比较,差异均无统计学意义(均P>0.05);治疗后,研究组PCT、ESR水平分别为(0.8±0.2)μg/L、(19.3±3.2)mm/h,均低于对照组,差异均有统计学意义(均P<0.05);治疗前,两组患者TNF-α、IL-6、TG指标比较,差异均无统计学意义(均P>0.05);治疗后,研究组TNF-α、IL-6、TG指标分别为(16.1±6.3)μg/L、(35.1±8.5)ng/L、(4.5±2.3)mmol/L,明显低于对照组,差异均有统计学意义(均P<0.05)。结论 应用左氧氟沙星联合肝素对血液透析导管感染患者进行干预,可明显改善患者WBC与CRP水平、PCT与ESR水平,同时能够降低炎性因子指标,提高安全性,改善患者预后。因此,左氧氟沙星与肝素应进一步推广和应用。
Objective To investigate the effect of levofloxacin combined with heparin on serum PCT and CRP levels in hemodialysis patients with catheter infection. Methods 82 hemodialysis patients with catheter infection admitted to our hospital from January 2017 to January 2018 were selected and were randomly divided into two groups. The control group was treated with levofloxacin, and the study group was treated with heparin on the basis of the control group. The incidence of adverse reactions, WBC and CRP levels, PCT and ESR levels, and inflammatory factors levels were compared between the two groups. Results There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). There were no statistically significant differences in WBC and CRP levels between the two groups before treatment (P>0.05). After treatment, the WBC and CRP levels in the study group [(4.1±2.2)×10^9/L,(5.1±2.3)mg/L] were lower than those in the control group (P<0.05). Before treatment, there were no statistically significant differences in PCT and ESR levels between the two groups (P>0.05). After treatment, the PCT and ESR levels in the study group [(0.8±0.2)μg/L,(19.3±3.2)mm/h] were lower than those in the control group (P<0.05). Before treatment, there were no statistically significant differences in TNF-α, IL-6, TG levels between the two groups (P>0.05). After treatment, the TNF-α, IL-6, and TG levels in the study group [(16.1±6.3)μg/L,(35.1±8.5)ng/L,(4.5±2.3)mmol/L] were significantly lower than those in the control group (P<0.05). Conclusion Levofloxacin combined with heparin can significantly improve WBC and CRP levels, PCT and ESR levels in hemodialysis patients with catheter infection, which can reduce inflammatory factors levels, improve safety, and improve patients’ prognosis. Therefore, levofloxacin and heparin should be further promoted and applied.
作者
崔连顺
于美言
Cui Lianshun;Yu Meiyan(Department of Nephrology,Weihai Central Hospital Affiliated to Qingdao University,Weihai 264400,China)
出处
《国际医药卫生导报》
2019年第18期3114-3117,共4页
International Medicine and Health Guidance News
