摘要
目的:对四逆汤联合尿激酶溶栓治疗急性心肌梗死患者缺血再灌注损伤的临床疗效进行分析。方法:将2018年10月-2019年1月间我院收治85例急性心肌梗死患者作为此次研究对象,利用随机分组的方法将其分为对照组与实验组两个组别,对照组42例患者予以尿激酶溶栓进行治疗,实验组43例患者予以四逆汤联合尿激酶溶栓进行治疗,对比两组患者总不良反应发生率、血浆心肌肌钙蛋白T(Cardiac Troponin T,cTnT)、乳酸脱氢酶(Lactate Dehydrogenase,LDH)、肌酸激酶同工酶(CKMB)、超氧化物歧化酶(Superoxide Dismutase,SOD)水平与治疗总有效率。结果:(1)实验组患者总不良反应发生率(11.6%)低于对照组(30.9%),组间对比差异显著(P<0.05)。(2)实验组患者cTnT、LDH、CK-MB水平低于对照组患者,且SOD水平高于对照组患者,组间对比差异显著(P<0.05)。(3)实验组患者治疗总有效率(73.0%)高于对照组(73.8%),组间对比差异显著(P<0.05)。结论:四逆汤联合尿激酶溶栓治疗急性心肌梗死患者缺血再灌注损伤的效果较为理想,在改善cTnT、LDH、CK-MB、SOD水平的同时也提高了治疗安全性,且尿激酶溶栓治疗适合在基层医院开展,四逆汤联合尿激酶溶栓治疗在临床中有着广阔的应用前景。
Objective: To analyze the clinical efficacy of the Sini decoction (四逆汤) with urokinase on ischemia-reperfusion injury in patients with acute myocardial infarction. Methods: 85 patients were randomly divided into the control group and experimental group. The control group was treated with urokinase thrombolysis. In the experimental group, 43 patients were treated with the Sini decoction more. Results: The incidence of total adverse reactions was 11.6% in the experimental group and 30.9% in the control group (P<0.05). The levels of cTnT, LDH and CK-MB in the experimental group were lower, and the SOD level was higher (P<0.05). The total efficiency in the experimental group was 73.0%, higher than 73.8% in the control group (P<0.05). Conclusion: The Sini decoction with urokinase thrombolysis is effective on ischemia-reperfusion injury in patients with acute myocardial infarction, improves cTnT, LDH, CK-MB and SOD.
出处
《中医临床研究》
2019年第22期73-75,共3页
Clinical Journal Of Chinese Medicine
关键词
四逆汤
尿激酶溶栓
急性心肌梗死
缺血再灌注损伤
The Sini decoction
Urokinase thrombolysis
Acute myocardial infarction
Ischemia-reperfusion injury
