摘要
胃癌在我国癌症发病率排行中仅次于肺癌,居于第2位,是消化系统中最常见的恶性肿瘤。热休克蛋白70(Hsp70)是热休克蛋白(HSPs)家族中最保守且最为重要的一族,具有分子伴侣、参与肿瘤免疫、参与细胞的增殖和凋亡调控、提高细胞的应激耐受性的生物学功能。研究发现,Hsp70可促进胃癌细胞的增殖,增强胃癌细胞的侵袭和迁移能力,与胃癌的发生发展密切相关。该文作者就Hsp70与胃癌的相关研究进展进行了综述。
Gastric cancer,which is the most common malignant tumor in the digestive system,ranks second in the morbidity of cancer in China,only to lung cancer.Heat shock protein (Hsp 70) is the most conservative and important family of heat shock proteins (HSPs),and it has the biological functions of molecular chaperone, participating in tumor immunity,regulating cell proliferation and apoptosis,and improving cell s tolerance to stress.Hsp70 which is closely related to the occurrence and development of gastric cancer,can promote the proliferation of gastric cancer cells and enhance the invasion and migration ability of gastric cancer cells.This article briefly reviews the research progress of Hsp70 and gastric cancer.
作者
龙明炬
黄秋林
LONG Mingju;HUANG Qiulin(Department of Gastrointestinal Surgery,theFirst Affiliated Hospital of University Of South China,Hengyang 421001,China)
出处
《中国肿瘤外科杂志》
CAS
2019年第4期296-299,共4页
Chinese Journal of Surgical Oncology
基金
南华大学研究生科学基金项目(2018KYY422)
关键词
HSP70
胃癌
热休克蛋白
Heat shock protein 70
Gastric cancer
Heatshock proteins
