摘要
吡啶-N-氧化物及其衍生物作为重要的氮杂环类化合物,在诸多领域中有着重要的应用价值,以氧化胺型査耳酮为底物,N,N-二甲基乙醇胺为配体,苯乙炔为亲核试剂,进行1,2加成反应,得到炔基醇类吡啶氮氧化物,收率高达98%。研究发现,反应对多种不同取代基的查耳酮底物均有较好的普适性,且反应产物结构中含有碳碳双键、碳碳三键、叔醇、吡啶氮氧基4个官能团,可进行多种途径的衍生。所有产物都经过1HNMR、13CNMR、HRMS鉴定。
Pyridine-N-oxide and its derivatives,as nitrogen heterocyclic compounds,have important application value in many fields.The reaction was achieved using the amine oxide type chalcone as the substrate,N,N-dimethylethanolamine as the ligand and phenylacetylene as the nucleophilic reagent to obtain the alkynol pyridine nitrogen oxide by 1,2 addition reaction.A series of substituted chalcone were applied to the reaction with up to 98% yield.These products contain carbon-carbon double bond,carboncarbon triple bond,tertiary alcohol,pyridyl azoxy group,which can be derivatized in various ways.All products were determined by1 HNMR,13 CNMR and HRMS techniques.
作者
徐嘉琪
夏曦
胡越高
陈煜
杨鸿均
赵志刚
陈峰
XU Jia-qi;XIA Xi;Hu Yue-gao;CHEN Yu;YANG Hong-jun;ZHA;CHEN Feng(College of Chemistry & Environment Protection Engineering,Southwest Minzu University,Chengdu 610041,China)
出处
《化学试剂》
CAS
北大核心
2019年第9期905-910,共6页
Chemical Reagents
基金
国家自然科学基金资助项目(21602183)
西南民族大学研究生“创新科研项目”(CX2018SZ134)
关键词
氧化胺型查耳酮
苯乙炔
1
2加成反应
氨基醇
amine oxide chalcones
phenylacetylene
1,2 addition reaction
amino alcohol
