摘要
目的探讨肺结核合并糖尿病采用胸腺肽α1联合抗结核方案治疗的疗效。方法选取本院2016年3月至2018年1月收治的肺结核合并糖尿病患者106例,按单盲法分为两组,各53例。对照组采用3HRZE/6HRE方案抗结核治疗,在此基础上,试验组加用胸腺肽α1治疗。连续治疗2个月后,比较两组临床疗效、痰菌转阴率、外周血T淋巴细胞亚群。结果治疗后,试验组总有效率(94.34%)、痰菌转阴率(92.45%)较对照组[(81.13%)、(77.36%)]高,差异具有统计学意义(χ^2=4.296、4.711,P=0.038、0.030);治疗后,试验组CD4^+(40.19±6.84)%、CD4^+/CD8^+(1.32±0.29)水平高于对照组[(35.26±7.15)%、(1.19±0.24)],CD8^+(24.85±3.65)%水平低于对照组(28.65±4.02)%,差异具有统计学意义(t=3.627、2.514、5.095,P=0.000、0.012、0.000)。结论肺结核合并糖尿病采用胸腺肽α1联合抗结核方案治疗可提高痰菌转阴率、临床疗效,增强患者的机体免疫功能。
Objective To investigate the effect of thymosin alpha 1 combined with anti-tuberculosis regimen on the treatment of pulmonary tuberculosis with diabetes mellitus. Methods 106 patients with pulmonary tuberculosis and diabetes mellitus admitted to our hospital from March 2016 to January 2018 were divided into two groups by single blind method,53 cases each. The control group was treated with 3HRZE/6HRE regimen. On this basis, the experimental group was treated with thymosin alpha 1. After 2 months of continuous treatment, the clinical efficacy, sputum negative conversion rate and peripheral blood T lymphocyte subsets were compared between the two groups. Result After treatment, the total effective rate (94.34%) and sputum negative conversion rate (92.45%) in the experimental group were higher than those in the control group [(81.13%) and (77.36%)] with statistical significance (x^2=4.296,4.711 ,P=0.038,0.030);after treatment,the levels of CD^4+(40.19+6.84)%, CD^4+/CD^8+( 1.32+0.29) in the experimental group were higher than those in the control group [(35.26 +7.15),(1.19+0.24)],CD^8+(24.85+3.65)% level was lower than that of the control group (28.65+4.02%). The difference was statistically significant (t=3.627,2.514,5.095,P=0.000,0.012,0.000). Conclusion Thymosin alpha 1 combined with anti -tuberculosis regimen can improve sputum negative conversion rate, clinical efficacy and immune function of patients with tuberculosis and diabetes mellitus.
作者
张亚平
Zhang Yaping(First Affiliated Hospital of Henan University of Science and Technology ,Luoyang, Henan ,471000)
出处
《口岸卫生控制》
2019年第4期38-41,共4页
Port Health Control
关键词
肺结核合并糖尿病
胸腺肽Α1
抗结核方案
外周血T淋巴细胞亚群
Tuberculosis with Diabetes Mellitus
Thymosin alpha 1
Antituberculosis Regimen
Peripheral Blood T Lymphocyte Subsets
