摘要
目的:研究铁皮枫斗胶囊的辅助降血脂功能,为开发新的保健品提供依据。方法:制备高脂饲料致大鼠高胆固醇血症动物模型,灌胃给予铁皮枫斗胶囊(800 mg/kg、400 mg/kg、200 mg/kg),于造模第2周及给药第2周(造模第4周)、第4周(造模第6周)测定血清四项TC、TG、LDL-C、HDL-C水平;给药第4周,测定血清ALT、AST,以及胆固醇酰基转运酶(ACAT)、卵磷脂胆固醇酰基转运酶(LCAT)水平。结果:与模型对照组相比,给药2周,800 mg/kg铁皮枫斗组大鼠TC、LDL-C水平显著降低(P<0.05)。给药4周,铁皮枫斗胶囊800 mg/kg、400 mg/kg组大鼠血清TC、LDL-C水平显著降低(P<0.01~0.05),800 mg/kg铁皮石斛组大鼠血清ALT显著降低(P<0.05),ELISA结果显示,800 mg/kg铁皮枫斗组大鼠血清LCAT升高。结论:铁皮枫斗胶囊能降低高脂血症大鼠TC、LDL-C水平,具有一定的辅助降血脂效果。
Objective:To study the effect of Dendrobium candicum capsules on reducing blood lipid,and provide the theoretical basis for development of new products function.Methods:Hyperlipidemia rat model was established by and fat diet.The hyperlipemia groups were fed with Dendrobium candicum orally at a dose of 800 mg/kg、400 mg/kg、200 mg/kg everyday.The serum levels of TC,TG,HDL-C,LDL-C were measured at the second week,fourth week and sixth week.The serum levels of ALT, AST, ACAT, LCAT were observed at the time of the sixth week.Results:Compared with hyperlipemia control group, the serum levels of total cholesterol(TC),low-density lipoprotein cholestol(LDL-C) were decreased in 800 mg/kg dose groups at the second week.And after 4 weeks, the serum levels of TC, LDL-C were decreased in the dose groups of 800 mg/kg and 400 mg/kg compared with hyperlipemia control groups.At the sixth week, the serum level of ALT in 800 mg/kg dose group was decreased, the serum level of LCAT was increased.Conclusion:Dendrobium candicum capsules have the function of reducing blood lipid auxiliary.
作者
唐琪晶
Tang Qijing(The Second Affiliated Hospital of Zhejiang University,Hangzhou 310009,China)
出处
《亚太传统医药》
2019年第8期32-35,共4页
Asia-Pacific Traditional Medicine
关键词
铁皮枫斗胶囊
辅助降血脂
胆固醇
Dendrobium Candicum
Auxiliary Reducing Blood
Cholesterol
