摘要
目的探究通脉降糖胶囊联合二甲双胍片治疗2型糖尿病的临床疗效。方法选择2016年9月-2018年1月喀什地区第一人民医院收治的138例2型糖尿病患者作为研究对象,所有患者按数字表法随机分为对照组和治疗组,每组各69例。对照组口服盐酸二甲双胍片,0.5g/次,2次/d。治疗组在对照组基础上口服通脉降糖胶囊,0.12g/次,3次/d。两组均连续治疗12周。观察两组的临床疗效,比较两组的血糖水平、血脂水平、免疫炎症指标。结果治疗后,对照组和治疗组的总有效率分别为73.91%、89.86%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者空腹血糖(FPG)、2h餐后血糖(2 h PBG)、糖化血红蛋白(HbA1c)水平均明显下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组FPG、2 h PBG、HbA1c水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均明显下降,高密度脂蛋白胆固醇(HDL-C)水平明显上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组TG、TC、LDL-C水平明显低于对照组,HDL-C水平明显高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者CD4^+、CD4^+/CD8^+均明显上升,C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平均明显下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组患者CD4^+、CD4^+/CD8^+明显高于对照组,CRP、TNF-α水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论通脉降糖胶囊联合二甲双胍片治疗2型糖尿病具有较好的临床疗效,可改善血糖血脂水平,增强免疫功能,降低炎症反应,具有一定的临床推广应用价值。
Objective To explore the clinical effect of Tongmai Jiangtang Capsules combined with Metformin Hydrochloride Tablets in treatment of type 2 diabetes mellitus. Methods Patients(138 cases) with type 2 diabetes mellitus in the First People’s Hospital of Kashi from September 2016 to January 2018 were randomly divided into control and treatment groups, and each group had 69 cases.Patients in the control group were po administered with Metformin Hydrochloride Tablets, 0.5 g/time, twice daily. Patients in the treatment group were po administered with Tongmai Jiangtang Capsules on the basis of the control group, 0.12 g/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and blood glucose levels,blood lipid levels, immune and inflammatory indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.91% and 89.86%, respectively, and there was difference between two groups(P < 0.05).After treatment, the levels of FPG, 2 h PBG, and HbA1c in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the blood glucose levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, TG, TC, and LDL-C levels in two groups were significantly decreased, but HDL-C levels in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the blood lipid levels in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, CD4^+ and CD4^+/CD8^+ in two groups were significantly increased, but CRP and TNF-α levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the immune and inflammatory indexes leve
作者
依丽米热·努尔麦麦提
赵红梅
热依汗尼沙·亚克亚
Yilimire Nuermaimaiti;ZHAO Hong-mei;Reyihannisha Yakeya(Department of Endocrinology, the First People’s Hospital of Kashi, Kashi 844000, China)
出处
《现代药物与临床》
CAS
2019年第8期2416-2419,共4页
Drugs & Clinic
关键词
通脉降糖胶囊
盐酸二甲双胍片
2型糖尿病
血糖
血脂
Tongmai Jiangtang Capsules
Metformin Hydrochloride Tablets
type 2 diabetes mellitus
blood glucose
blood lipid
