摘要
目的探究男性酒精使用障碍患者注意网络功能的损害情况以及注意网络功能的主要影响因素。方法选取41例经戒断治疗后的酒精使用障碍患者(Alcohol use disorder,AUD)以及与其人口学资料相匹配的34例正常对照组(Health controls,HC)作为研究对象,采用注意网络功能研究范式(attention network test,ANT)进行注意网络功能测试。结果与正常对照组相比[(30.62±19.74)ms,(98.59±1.46)%],酒精使用障碍组在注意网络功能测验中的警觉网络[(17.02±26.42)ms,t=-2.479,P=0.015]以及正确率[(95.07±10.73)%,t=-2.074,P=0.044]均差异有统计学意义。Pearson相关显示酒精使用障碍的警觉网络与首次饮酒年龄呈负相关(r=-0.316,P=0.044),与宾西法尼亚酒精渴求量表(Penn alcohol craving scale,PACS)得分成正相关(r=0.364,P=0.019);酒精使用障碍患者注意网络功能的正确率与患者教育年限(r=-0.343,P=0.028)和成瘾年数(r=-0.337,P=0.031)呈负相关。多元线性回归分析显示酒精使用障碍患者的注意网络功能受到患者的首次饮酒年龄(β=0.432,t=2.079,P=0.046)、成瘾年数(β=-0.555,t=-3.127,P=0.004)以及无序饮酒年数(β=0.309,t=2.074,P=0.047)的影响。结论酒精使用障碍患者注意功能中的警觉网络存在缺陷,并且酒精使用障碍患者注意功能受其饮酒情况影响。
Objective To explore the impairment of attention network function in male patients with alcohol use disorder(AUD) and the main influencing factors of attention network function. Methods Forty-one patients with AUD after withdrawal therapy and 34 healthy controls (HC) matched with their demographic data were selected as subjects of study.Attention function were assessed by attention network test (ANT). Results Compared with the healthy control group((30.62±19.74)ms,(98.59±1.46)%), there were significant differences in the reaction time of alerting network(t=-2.479, P=0.015) and the correct rate of the attention network test(t=-2.074, P=0.044) in the AUD group((17.02±26.42)ms,( 95.07±10.73)%). Pearson correlation analysis showed the alert network of AUD was negatively correlated with the age of first drinking(r=-0.316, P=0.044) and was positively correlated with the score of Penn alcohol craving scale(PACS)(r=0.364, P=0.019). The correct rate of attention network function in patients with AUD was negatively correlated with the years for education(r=-0.343, P=0.028) and years for addiction(r=-0.337, P=0.031). Linear regression analysis showed the attention network function of AUD patients was affected by the age of first drinking(β=0.432, t=2.079, P=0.046), the years for addiction(β=-0.555, t=-3.127, P=0.004) and years for uncontrol drinking(β=0.309, t=2.074, P=0.047). Conclusion The AUD patients were demonstrated deficit in the alerting network.The impairment of attention function of AUD patients were influenced by their drinking condition.
作者
陶睿
庞良俊
芮琴琴
汪咏梅
Tao Rui;Pang Liangjun;Rui Qinqin;Wang Yongmei(Affiliated Psychological Hospital of Anhui Medical University,Hefei 230022,China;Department of Substance-Related Disorders,Anhui Mental Health Center,Hefei 230022,China;Department of Psychology,Chaohu Hospital of Anhui Medical University,Hefei 238000,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2019年第8期716-720,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(31771221)
安徽省精神卫生中心支持项目(2017008
2018ZD07).
关键词
酒精使用障碍
认知功能
注意
注意网络功能测试
Alcohol use disorder
Cognitive function
Attention
Attention network test
