摘要
目的探讨自噬相关蛋白16样蛋白1(autophagy related protein 16 like protein 1,ATG16L1)、半乳糖凝集素9(galectin-9,Gal-9)、白细胞介素1β(interleukin-1β,IL-1β)、白细胞介素33(interleukin-33,IL-33)在溃疡性结肠炎(ulcerative colitis,UC)静息期和发病期的表达差异及临床意义。方法选择UC患者110例按照Mayo评分分为静息期UC组和发病期UC组,同时选择健康体检者40例作为对照组。比较3组血清ATG16L1、Gal-9、IL-1β、IL-33水平,分析其与Mayo评分的相关性,并进行UC发病期的多因素Logistic多元回归分析。结果静息期UC组和发病期UC组血清IL-1β、IL-33、ATG16L1、Gal-9水平显著高于对照组,发病期UC组血清IL-1β、IL-33、ATG16L1、Gal-9水平显著高于静息期UC组,差异均有统计学意义(P<0.05)。血清IL-1β、IL-33、ATG16L1、Gal-9水平与Mayo评分均呈正相关(P<0.05)。多因素Logistic回归分析结果显示,血清IL-1β、IL-33、ATG16L1、Gal-9是UC发病期的影响因素。结论发病期UC患者血清IL-1β、IL-33、Gal-9、ATG16L1水平更高,可作为发病期UC的判断因素。
Objective To investigate the differential expression and clinical significance of autophagy related protein 16 like protein 1(ATG16L1),galectin-9(Gal-9),interleukin-1β(IL-1β)and interleukin-33(IL-33)in patients of ulcerative colitis(UC)at rest and onset.Methods One hundred and ten patients with UC were selected as study group.According to the Mayo score,the patients were divided into the resting UC group and the onset UC group,and 40 healthy subjects were selected as the control group.The levels of serum ATG16L1,Gal-9,IL-1βand IL-33 were compared between the three groups,and their correlation with the Mayo score was analyzed.Multivariate Logistic regression analysis of UC onset period was performed.Results The serum levels of IL-1β,IL-33,ATG16L1,and Gal-9 in the resting UC group and the onset UC group,were significantly higher than those in the control group(P<0.05),the active UC group was significantly higher than those of the resting UC group(P<0.05).The serum levels of IL-1β,IL-33,ATG16L1 and Gal-9 were positively correlated with Mayo score(P<0.05).Multivariate logistic regression analysis showed that IL-1β,IL-33,ATG16L1,and Gal-9 were the influencing factors of UC in the onset.Conclusion The serum levels of IL-1β,IL-33,Gal-9 and ATG16L1 are higher in patients with UC in the onset,which can be used as an independent judgment factor for UC in the onset.
作者
吴娜
李多
高会斌
于永强
杨婕琳
WU Na;LI Duo;GAO Hui-bin;YU Yong-qiang;YANG Jie-lin(Department of Gastroenterology,the First Affiliated Hospital of Hebei NorthUniversity,Zhangjiakou 075000,China)
出处
《河北医科大学学报》
CAS
2019年第9期1013-1016,共4页
Journal of Hebei Medical University
基金
河北省医学科学研究重点课题(20160368)
