摘要
目的探讨达英-35联合二甲双胍治疗多囊卵巢综合征(PCOS)对患者性激素、胰岛素抵抗的影响。方法选择2017年1月至2018年12月空军军医大学西京医院妇产科收治的168例PCOS患者为研究对象,根据随机数表法将患者分为观察组与对照组,每组84例,对照组患者给予达英-35治疗,观察组在此基础上联合应用二甲双胍治疗,疗程均为3个月。比较两组患者治疗前后的空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)以及性激素水平[促卵泡生成素(FSH)、黄体生成素(LH)、睾酮(T)、泌乳素(PRL)、雌二醇(E2)];随访3个月,比较两组患者的排卵率及妊娠率。结果治疗后,观察组患者的血清LH、PRL、T水平分别为(8.74±1.24) U/L、(15.50±2.22) pmol/L、(1.98±0.84) nmol/L,明显低于对照组的(9.93±1.27) U/L、(17.46±2.32) pmol/L、(2.25±0.52) nmol/L,E2为(59.49±4.65) pmol/L,明显高于对照组的(53.44±5.34) pmol/L,差异均有统计学意义(P<0.05);治疗后,观察组患者FINS及HOMA-IR水平分别为(14.82±4.47) m U/L、2.27±0.79,明显低于对照组的(22.12±6.24) mU/L、3.46±1.08,差异有统计学意义(P<0.05);随访3个月,观察组患者的排卵率及妊娠率分别为78.57%、51.19%,均明显高于对照组的61.90%、35.71%,差异均有统计学意义(P<0.05)。结论达英-35联合二甲双胍应用于多囊卵巢综合征的治疗,与单用达英-35比较,可以改善胰岛素抵抗状态,更加有效地调节性激素水平,提高促排卵效果及妊娠率。
Objective To investigate the effects of Diane-35 combined with metformin on sex hormones levels and insulin resistance in patients with polycystic ovary syndrome (PCOS). Methods A total of 168 patients with PCOS were selected as subjects, who were admitted to the Department of Obstetrics and Gynecology at Xijing Hospital of Air Force Military Medical University from January 2017 to December 2018. According to the random number table method, the patients were divided into observation group and control group, with 84 cases in each group. The control group was treated with Diane-35, and the observation group was additionally treated with metformin on the basis of the control group. Both groups treated for 3 months. The fasting insulin (FINS) levels and insulin resistance index (HOMA-IR) were compared between the two groups before and after treatment, as well as some sex hormones levels including follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin (PRL), and estradiol (E2). After 3 months of follow-up, the ovulation rate and pregnancy rate were compared between the two groups. Results In the observation group, the serum levels of LH, PRL and T after treatment were (8.74±1.24) U/L,(15.50± 2.22) pmol/L,(1.98 ± 0.84) nmol/L, respectively, which was significantly lower than corresponding (9.93 ± 1.27) U/L,(17.46±2.32) pmol/L,(2.25±0.52) nmol/L in the control group;and E2 was (59.49±4.65) pmol/L, which was significantly higher than (53.44±5.34) pmol/L in the control group (P<0.05). After treatment, the levels of FINS and HOMA-IR in the observation group was respectively (14.82±4.47) mU/L and 2.27±0.79, which was significantly lower than corresponding (22.12±6.24) mU/L and 3.46±1.08 in the control group (P<0.05). After 3 months of follow-up, the ovulation rate (78.57% vs 61.90%) and pregnancy rate (51.05% vs 35.71%) in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Diane-35 combined with metformin for the treatment of po
作者
李砚
王运萍
姚念玲
白璐
赵海波
陈必良
王海旭
LI Yan;WANG Yun-ping;YAO Nian-ling;BAI Lu;ZHAO Hai-bo;CHEN Bi-liang;WANG Hai-xu(Department of Obstetrics and Gynecology,Xijing Hospital of Air Force Military Medical University,Xi'an 710032,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第17期2203-2205,共3页
Hainan Medical Journal
基金
空军军医大学2018年学科助推计划自由探索项目(编号:XJZT18MJ26)
