摘要
目的探讨和分析在先兆流产患者中黄体酮对围生儿结局与妊娠期合并症产生的影响。方法该次抽选2016年1月-2018年1月在该院医治的先兆流产患者(100例)做甲组,并选同期100名健康妊娠女性做乙组,乙组常规孕期干预,在此基础上甲组加黄体酮,总结围生儿结局、妊娠期合并症、人孕激素诱导阻断因子、血清孕酮水平。结果甲组的胎儿畸形率(2.0%)、巨大儿率(4.0%)、低体重儿率(4.0%)、难免流产率(2.0%)、1 min新生儿评分低于7分率(4.0%)、胎儿窘迫率(6.0%)、早产率(10.0%)均高于乙组(1.0%、2.0%、2.0%、0.0%、2.0%、4.0%、6.0%),差异无统计学意义(χ2=0.338,P=0.561;χ2=0.687,P=0.407;χ2=0.687,P=0.407;χ2=2.020,P=0.155;χ2=0.687,P=0.407;χ2=0.421,P=0.516;χ2=1.087,P=0.297)。甲组的妊娠期胆汁淤积率(8.0%)、妊娠期高血压率(6.0%)、胎盘前置率(3.0%)、妊娠期糖尿病率(6.0%)、胎盘早剥率(2.0%)、胎膜早破率(15.0%)均高于乙组(6.0%、5.0%、2.0%、5.0%、1.0%、13.0%),差异无统计学意义(χ2=0.307,P=0.579;χ2=0.096,P=0.756;χ2=0.205,P=0.651;χ2=0.096,P=0.756;χ2=0.338,P=0.561;χ2=0.166,P=0.684)。甲组的人孕激素诱导阻断因子水平(497.11±113.25)ng/mL低于乙组(502.32±114.26)ng/mL,差异无统计学意义(t=0.324,P=0.746)。甲组的血清孕酮水平(87.25±15.38)nmol/L高于乙组(73.21±11.26)nmol/L,差异有统计学意义(t=7.366,P=0.000)。结论在先兆流产患者中,黄体酮可降低患者妊娠期合并症发生的概率,并改善围生儿结局。
Objective To investigate and analyze the effect of progesterone on perinatal outcome and complications of pregnancy in threatened abortion patients. Methods A total of 100 threatened abortion patients treated in our hospital from January 2016 to January 2018 were selected as group A(n=100). And 100 healthy pregnant women in the same period were selected as group B. Group B received routine pregnancy intervention. On this basis, progesterone was added to group A. Perinatal outcomes, pregnancy complications, human progesterone induction blocking factor and serum progesterone level were summarized. Results The fetal malformation rate(2.0%), macrosomia rate(4.0%), low birth weight rate(4.0%), inevitable abortion rate(2.0%), the rate of neonatal score less than 7 points(4.0%), fetal distress rate(6.0%), and premature delivery rate(10.0%) in group A were higher than those in group B(1.0%, 2.0%,2.0%, 0.0%, 2.0%, 4.0%, 6.0%). But the difference was not significant(χ2=0.338, P=0.561;χ2=0.687, P=0.407;χ2=0.687, P =0.407;χ2=2.020, P =0.155;χ2=0.687, P =0.407;χ2=0.421, P =0.516;(χ2=1.087, P =0.297). The pregnancy cholestasis rate(8.0%), pregnancy hypertension rate(6.0%), placental preposition rate(3.0%), gestational diabetes mellitus rate(6.0%), placental abruption rate(2.0%) and premature rupture rate of membranes(15.0%) in group A were higher than those in group B(6.0%, 5.0%, 2.0%, 5.0%, 1.0%) and(13.0%)]. But the difference was not significant(χ2=0.307, P=0.579;χ2=0.096, P=0.756;χ2=0.205, P=0.651;χ2=0.096, P=0.756;χ2=0.338, P=0.561;χ2=0.166, P=0.684).The level of progesterone-induced blocking factor in group A was(497.11±113.25) ng/mL, which was lower than that in group B(502.32±114.26) ng/mL, but the difference was not significant(t=0.324, P=0.746). The serum progesterone level in group A was(87.25±15.38) nmol/L, which was higher than that in group B(73.21±11.26) nmol/L, and the difference was significant(t=7.366, P=0.000). Conclusion For patients with threatened abortion, progesterone can reduce the inc
作者
冯莉
康子霞
王秀珍
庄明莲
ENG Li;KANG Zi-xia;WANG Xiu-zhen;ZHUANG Ming-lian(Department of Obstetrics, Qingzhou People's Hospital, Qingzhou, Shandong Province 262500 China;Department of Pharmacy, Qingzhou People's Hospital,Qingzhou, Shandong Province 262500 China)
出处
《系统医学》
2019年第15期143-146,共4页
Systems Medicine
关键词
黄体酮
先兆流产
围生儿结局
妊娠期合并症
影响
Progesterone
Threatened abortion
Perinatal outcome
Pregnancy complications
Impact
