摘要
目的比较采用四联疗法与含痢特灵序贯疗法治疗幽门螺杆菌(HP)阳性初治失败患者的临床效果。方法选取2016年8月至2018年8月在我院治疗的HP阳性初治失败患者60例为研究对象,采用随机数字表法分为观察组与对照组,每组30例。观察组患者采用含痢特灵的序贯方案治疗,即患者在接受奥美拉唑+阿莫西林治疗5d后再使用奥美拉唑+痢特灵+克拉霉素治疗;对照组患者采用四联方案治疗,即患者接受奥美拉唑+阿莫西林+替硝唑+胶体果胶铋治疗。治疗10d为1个疗程,两组患者均连续治疗3个疗程,比较两组患者的临床症状评分、临床疗效以及不良反应发生情况。结果治疗3个疗程后,两组患者的临床症状评分均显著降低,观察组患者的评分显著低于对照组,差异有统计学意义(P<0.05);观察组患者的治疗总有效率(96.7%)高于对照组(83.3%),但差异无统计学意义(P>0.05)。治疗过程中,观察组患者的不良反应发生率(13.3%)显著低于对照组(33.3%),差异有统计学意义(P<0.05)。结论对HP阳性初治失败患者,采用含痢特灵的序贯疗法进行治疗的临床效果优于采用四联疗法治疗,可更有效地改善患者的临床症状,降低不良反应发生率。
Objective To compare the clinical effects of quadruple therapy and furazolidone sequential therapy for patients with Helicobacter pylori (HP) positive in the initial failure treatment.Methods 60 patients with HP-positive in the initial failure treatment,who were treated in our hospital from August 2016 to August 2018,were enrolled as the objects.They were randomly divided into observation group and control group,with 30 cases in each group.Patients in the observation group were treated with sequential therapy containing furazolidone;namely,after 5 days treating with omeprazole plus amoxicillin,they were then treated with omeprazole plus furazolidone and clarithromycin,whereas patients in the control group were treated with quadruple therapy,in other words,they were treated with omeprazole plus amoxicillin,tinidazole,and colloidal bismuth pectin.Both groups of patients were treated continuously for 3 courses,and 10 days as a course.The clinical symptom scores,clinical efficacy,and adverse reactions between the two groups were compared.Results After 3 courses of treatment,the clinical symptom scores of the two groups were significantly decreased,and the scores of the observation group were significantly lower than the control group,with statistically significant differences ( P <0.05);the total effective rate of treatment in the observation group (96.7%) was significantly higher than the control group (83.3%),but the difference was not statistically significant ( P >0.05).During the treatment,the incidence of adverse reactions in the observation group (13.3%) was significantly lower than the control group (33.3%),with statistically significant differences ( P <0.05).Conclusion The clinical effect of employing sequential therapy containing furazolidone is significantly better than quadruple therapy for patients with HP-positive in the initial failure treatment,which can effectively improve patients′ clinical symptoms and reduce the incidence of adverse reactions.
作者
马燕
杨廷旭
李茜
王晓辉
薛宝凤
赵振国
MA Yan;YANG Tingxu;LI Qian;WANG Xiaohui;XUE Baofeng;ZHAO Zhenguo(Department of Internal Medicine,Jiuquan City People′s Hospital (Southeast Campus),Jiuquan 735000,Gansu Province,China)
出处
《内科》
2019年第4期408-410,461,共4页
Internal Medicine
关键词
幽门螺杆菌
初治失败
痢特灵
序贯疗法
Helicobacter pylori
Initial failure treatment
Furazolidone
Sequential therapy
