摘要
目的探讨T2DM患者在应用二甲双胍治疗时的消化道不良反应与幽门螺杆菌(HP)感染的关系。方法选取130例新诊断T2DM患者,根据碳-13呼气试验结果,分为HP感染阳性组(HP)59例和阴性组(Con)71例,均小剂量起始给予二甲双胍降糖治疗,持续观察4周,根据血糖及消化道耐受情况调整剂量,比较两组的消化道反应。结果应用二甲双胍治疗4周后,HP组和Con组分别有64. 41%和30. 99%的患者出现消化道反应(P=0. 001),HP组与Con组腹胀比例分别为33. 89%和14. 08%(P=0. 008),厌食比例分别为27. 12%和8. 45%(P=0. 005),腹痛比例分别为25. 42%和9. 86%(P=0. 018)。HP组的二甲双胍耐受剂量小于Con组[(1156. 78±30. 89)vs(1352. 82±490. 62)mg,P=0. 014)]。结论 HP感染的T2DM患者应用二甲双胍更易出现消化道不良反应,HP感染降低了二甲双胍的耐受性。
Objective To investigate the correlation between gastrointestinal adverse effects of Metformin and Helicobacter pylori infection in patients with newly diagnosed type 2 diabetes mellitus(T2 DM).MethodsA total of 130 patients with newly diagnosed T2 DM were enrolled in this study. All the patients were divided into two groups according to13 C-labeled urea breath test:H. pylori infection group(HP group,n=59)and control group(Con group,n=71). All the subjects were treated with a small dose of Metformin. The dose of Metformin was adjusted by glucose and gastrointestinal side effects every week. All the subjects were followed up for 4 weeks. Gastrointestinal side effects were compared between the two groups.ResultsAfter treatment with Metformin for 4 weeks,the incidence of gastrointestinal side effects were64. 41% and 30. 99%(P=0. 001). The incidence of bloating were 33. 89% versus 14. 08%(P=0. 008),anorexia 27. 12% versus 8. 45%(P=0. 005),abdominal pain 25. 42% versus 9. 86%(P=0. 018)in HP group and NC group respectively. The final Metformin tolerant dose was lower in HP group than in Con group[(1156. 78±30. 89)vs(1352. 82±490. 62)mg,P=0. 014)].ConclusionHelicobacter pylori infection may decrease Metformin tolerance in patients with T2 DM.
作者
王海娇
李丽疆
朱蕾
石保昌
王祥香
WANG Haijiao;LI Lijiangy;ZHU Lei(Department of Endocrinology , Shandong Provincial Third Hospital, Jinan 250000, China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2019年第8期607-610,共4页
Chinese Journal of Diabetes
关键词
糖尿病
2型
二甲双胍
消化道反应
HP
感染
Diabetes mellitus,type 2
Metformin
Digestive tract reaction
Helicobacter pylori
Infection
