摘要
环状RNA(circular RNA,circRNA)是一类广泛表达于真核细胞的环形RNA,多起源于蛋白编码基因。近年来发现circRNAs可通过如miRNA"海绵"等作用模式在基因的表达中发挥重要的调控作用,存在器官组织特异性的表达谱,并且越来越多的证据表明circRNAs可能是一种潜在的疾病标志物和治疗靶点。本文将对circRNAs近年在疾病中的研究进展进行综述,具体分为以下几个方面:(1)circRNAs的基本特征;(2)circRNAs的合成调控;(3)环状RNA介导基因表达的调控机制;(4)circRNAs在肿瘤性疾病中的作用;(5)circRNAs在感染免疫相关性疾病中的作用;(6)circRNAs在心血管疾病中的作用;(7)研究展望。
Circular RNA(circRNA)is widely expressed in eukaryotic cells,which originates from protein-coding genes.It has been found that circRNAs can play an important regulatory role in gene expression through a mode of action such as miRNA"sponge",having organ-specific expression profiles.There is increasing evidence that circRNAs may be potential disease markers and therapeutic targets.In this paper,the research progress of circRNAs in diseases in recent years is reviewed,including the following aspects:(1)basic characteristics of circRNAs;(2)synthetic regulation of circRNAs;(3)regulation of circular RNA-mediated gene expression mechanisms;(4)the role of circRNAs in neoplastic diseases;(5)the role of circRNAs in infection-related immune diseases;(6)the role of circRNAs in cardiovascular diseases.The future research trend in this field is also predicted.
作者
张蕾
张克明
方文捷
刘晓刚
郑方伟
潘炜华
廖万清
ZHANG Lei;ZHANG Ke-Ming;FANG Wen-Jie;LIU Xiao-Gang;ZHENG Fang-Wei;PAN Wei-Hua;LIAO Wan-Qing(Department of Dermatology,the Second Affiliated Hospital of Naval Military Medical University,Shanghai 200003,China;Department of Dermatology,Chinese Medicine Hospital of Yuhang,Hangzhou,Zhejiang 311106,China)
出处
《菌物学报》
CAS
CSCD
北大核心
2019年第8期1213-1222,共10页
Mycosystema
基金
上海市青年科技英才扬帆计划(19YF1448000)
上海市真菌病与自身免疫性疾病临床医学中心项目(2017ZZ01024-001)
“海上丝绸之路”重要病原体的威胁感知和监测预警项目(2018ZX10101003)
上海市医学真菌分子生物学重点实验室项目(17DZ2270900)
国家自然科学基金面上项目(31770161)~~
