摘要
随着人类平均寿命的延长,骨质疏松症在老年人群中的发病率逐年升高,严重影响老年人的身心健康。传统中药历史悠久,药效确切且毒性较小,因此多用于治疗骨质疏松症。不过中药成分复杂,作用机制不明是一个巨大的挑战。新学科概念网络药理学的兴起正好解决了这个问题,将网络药理学的思想和方法应用于中药药理研究,在分子网络调控的背景下研究中药的作用机制已成为一种新的趋势,是进一步推动骨质疏松防治工作发展的主要途径。本文将就网络药理学在中药治疗骨质疏松症中的应用作一综述。
With the increase of life expectancy,the incidence of osteoporosis increases year by year in the elderly,which seriously affects their physical and mental health. Traditional Chinese medicine has a long history,with definite efficacy and less toxicity,so it is often used to treat osteoporosis. However,the complex composition and unknown mechanism of TCM are a great challenge. The rise of the new scientific concept of network pharmacology is just right to solve this problem. Applying the ideas and method of network pharmacology in traditional Chinese medicine pharmacology research,has become a new trend to explore the mechanism of action of traditional Chinese medicine under the background of the molecular network regulation,and is an important way to further promote the development of osteoporosis prevention and treatment. This article reviews the application of network pharmacology in the treatment of osteoporosis using traditional Chinese medicine.
作者
黄景文
李生强
陈娟
谢丽华
陈玄
葛继荣
HUANG Jingwen;LI Shengqiang;CHEN Juan;XIE Lihua;CHEN Xuan;GE Jirong(Key Research Laboratory of Osteoporosis Syndrome Genomic, Fujian Academy of Traditional Chinese Medicine, Fuzhou350001,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2019年第8期1181-1184,1191,共5页
Chinese Journal of Osteoporosis
关键词
传统中药
网络药理学
数据库
骨质疏松症
traditional Chinese medicine
network pharmacology
database
osteoporosis
