摘要
目的研究磁共振弥散加权成像(DWI)应用于宫颈癌放疗效果及预后评估的价值.方法选择2017年1月至2018年1月在我院放疗的42例宫颈癌患者作观察组,再选择同期行盆腔磁共振成像(MRI)检查的42例非宫颈癌患者作对照组.2组患者治疗前后均做磁共振成像(MRI)和DWI检查,比较2组的表观扩散系数(ADC)值,不同病理、疗效时的ADC差异.结果对照组的ADC值为(1.59±0.31)×10^-3 mm^2/s,观察组为(0.83±0.25)×10^-3 mm^2/s,2组比较差异有统计学意义(P<0.05).腺癌、鳞癌的ADC值差异无统计学意义(P>0.05)无可比性.低分化肿瘤的ADC值,明显比中分化肿瘤、高分化肿瘤低,差异有统计学意义(P<0.05).Ⅰ期、Ⅱ期、Ⅲ期的ADC值差异无统计学意义(P>0.05).放疗前,观察组42例患者中,22例全部缓解(CR),20例部分缓解(PR).CR、PR患者放疗前的ADC值比较差异无统计学意义(P>0.05),放疗后,CR、PR患者的ADC值都明显升高,分别为(1.43±0.26)×10^-3 mm^2/s、(1.19±0.35)×10^-3 mm^2/s,CR、PR患者放疗后的ADC值比较差异有统计学意义(P<0.05).结论 DWI能够把宫颈癌组织特点准确反映出来,ADC值对宫颈癌的恶性程度、放疗效果均能客观评估,具有重要的临床研究价值.
Objective To study the value of diffusion-weighted imaging(DWI) in evaluating the radiotherapeutic effect and prognosis of cervical cancer. Methods Forty-two patients with cervical cancer who received radiotherapy in our hospital from January 2017 to January 2018 were selected as observation group, and 42 patients with noncervical cancer who underwent pelvic magnetic resonance imaging(MRI) at the same time were selected as control group. Both groups were examined by MRI and DWI before and after treatment. The apparent diffusion coefficient(ADC) values and the differences of ADC between the two groups in different pathology and curative effect were compared. Results The average ADC value of the control group was(1.59±0.31)×10^-3 mm^2/s and that of the observation group was(0.83±0.25)×10^-3 mm^2/s. There was significant difference between the two groups(P<0.05). It is comparable.There was no significant difference in ADC between adenocarcinoma and squamous cell carcinoma(P>0.05).The ADC values of poorly differentiated tumors were significantly lower than those of moderately differentiated and highly differentiated tumors,there was significant difference(P<0.05), which was comparable. There was no significant difference in ADC value between stage Ⅰ,stage Ⅱ and stage Ⅲ(P>0.05). Before radiotherapy, 22 of the 42 patients in the observation group were completely relieved(CR) and 20 were with partial remission(PR).There was no significant difference in ADC between CR and PR patients before radiotherapy(P>0.05).After radiotherapy, the ADC values of CR and PR patients were significantly increased, which were(1.43±0.26)×10^-3 mm^2/s,(1.19±0.35)×10^-3 mm^2/s, respectively. The ADC values of CR and PR patients after radiotherapy were significantly different(P<0.05),with statistical significance.Conclusion DWI can accurately reflect the histological characteristics of cervical cancer. ADC value can objectively evaluate the malignant degree and radiotherapy effect of cervical cancer, and has important clinical re
作者
刘士梅
Liu Shimei(Department of Radiology, Affiliated Hospital of Henan Medical College,Zhengzhou 453311,China)
出处
《实用医学影像杂志》
2019年第4期377-378,共2页
Journal of Practical Medical Imaging
关键词
磁共振成像
弥散
宫颈肿瘤
放疗疗效
预后评估
Diffusion magnetic resonance imaging
Uterine cervical neoplasms
Radiotherapy efficacy
Prognosis evaluation
