摘要
目的探讨不同剂量A型肉毒毒素治疗腋臭患者的临床效果。方法2016年2月至2018年2月,南京大学医学院附属鼓楼医院整形烧伤科根据腋臭病情分级选取200例腋臭患者,其中轻中度100例,重度100例,分别分为100 U组和200 U组两个亚组,各50例。两组患者双侧腋窝分别注射A型肉毒毒素100 U和200 U,比较两组术后有效率和复发率。结果在随访期内,轻中度腋臭患者两组有效率及复发率差异无统计学意义(均P>0.05)。重度腋臭患者,治疗3个月后100 U组有效率64.0%,200 U组有效率82.0%,差异有统计学意义(χ^2=4.110,P<0.05)。经过6个月随访,100 U组复发率46.0%,200 U组复发率22.0%,差异有统计学意义(χ^2=6.417,P<0.05)。结论基于腋臭的严重程度分级选择合适剂量A型肉毒毒素,可达到个体化的精准治疗,提高患者满意度。
Objective To explore the therapeutic effect of different doses of botulinum toxin A injections on bromhidrosis. Methods A total of 200 cases were divided into mild-to-moderate group (N=100) and severe group (N=100) based on the grade of bromhidrosis, and each group was further divided into two groups: low dose group (50 cases) were treated by botulinum toxin A injections (100 U) and high dose group (50 cases) were treated with 200 U for bilateral axillary. The total effective rate and recurrence rate in both groups were compared. Results In the mild to moderate group, after treatment for 3 months, the total effective rate of both groups had no statistical difference (P>0.05), and the same with recurrence rate in 6 months follow-up (P>0.05). In the severe group, after treatment for 3 months, the total effective rate of the high dose group (82%) was significantly higher than that of the low dose group (64%), with statistical significance (χ^2=4.110, P<0.05). After 6 months follow-up, recurrence rate in the high dose group (22%) was significantly lower than that of the low dose group(46%), with statistical significance (χ^2=6.417, P<0.05). Conclusions A suitable dose of botulinum toxin A can be selected based on the severity of bromhidrosis, which is a individualized therapy for cost savings and might have potential benefits for patients with osmidrosis.
作者
赵德梅
蒋亚楠
王淑琴
许澎
郑东风
吴杰
谭谦
Zhao Demei;Jiang Yanan;Wang Shuqin;Xu Peng;Zheng Dongfeng;Wu Jie;Tan Qian(Department of Burns and Plastic Surgery,Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《中华医学美学美容杂志》
2019年第4期296-298,共3页
Chinese Journal of Medical Aesthetics and Cosmetology
关键词
臭汗症
肉毒毒素类
A型
剂量效应关系
药物
治疗结果
病情分级
Bromidrosis
Botulinum toxins, type A
Dose-response relationship, drug
Treatment outcome
Disease classification
