摘要
目的探讨孕妇维生素D水平与妊娠期贫血的相关性。方法选择2015年12月到2016年2月在西安交通大学第一附属医院产科门诊产检的孕妇(孕周≤12周)4 532例,剔除已诊断的贫血孕妇,对观察对象进行基线调查,并随访5次至孕妇分娩。采用巢式病例对照研究,将本次随访期间新发贫血的383例作为病例组,按照1∶2频数匹配,随机抽取年龄(±2岁)、孕期居住地基本相同的766例正常孕妇作为对照组。采用t检验、χ^2检验、Mann-Whitney U检验、Logistic回归分析方法,分析孕妇维生素D水平与妊娠期贫血的相关性。结果在383例新发贫血孕妇中,71.5%的孕妇血清25(OH)D浓度低于50.0nmol/L,而对照组为60.1%,两组维生素D水平差异有统计学意义(P<0.05)。Logistic回归结果显示:与50~75nmol/L血清25(OH)D组孕妇相比,<30、30~50nmol/L组妊娠期贫血的发生风险均增加。通过校正混杂因素后,孕妇血清25(OH)D浓度<50nmol/L时,较50~75nmol/L组孕妇发生贫血风险增加74%(OR:1.74,95%CI:1.27~2.38)。结论维生素D缺乏与妊娠期贫血显著相关,应该重视妊娠期妇女维生素D水平的监测。
Objective To investigate the correlation between vitamin D concentration and gestational anemia.Methods For this study we recruited 4532 pregnant women (≤12 pregnant weeks) who received the pregnancy care in obstetrics outpatient in The First Affiliated Hospital of Xi'an Jiaotong University from December 2015 to February 2016;those with anemia were excluded.Baseline survey and follow-up till childbirth were conducted among them.We carried out a nested case-control study with a 1∶2 ratio.Three hundred and eighty-eight pregnant women with anemia detected in this study served as case group, while 766 pregnant women without anemia randomly selected and matched by age (±2 years), gestational habitual residence served as control group.And t test,χ^2 test, Mann-Whitney U test and logistic regression analysis were conducted to identify the association between vitamin D concentration and gestational anemia.Results Among the 383 pregnant women with anemia, 71.5% of them had serum 25(OH)D concentration <50.0 nmol/L, while 60.1% in the control group.The difference of vitamin D level in the two groups was significant ( P <0.05).Logistic regression analysis indicated that women with 25(OH)D concentration <30 nmol/L and 30-50 nmol/L had an increased risk of gestational anemia when compared with women with the concentration of 50-75 nmol/L.After adjustment for confounders, for women with concentration <50.0 nmol/L, they had an 74%( OR :1.74, 95% CI :1.27-2.38) increase in anemia risk when compared with those with the concentration of 50-75 nmol/L.Conclusion Vitamin D deficiency is significantly associated with gestational anemia, suggesting that we should pay attention to monitoring women s vitamin D concentration.
作者
廖侠
鲜瑶
宋戈
于志鹏
魏玲玲
靳菊英
李卫敏
LIAO Xia;XIAN Yao;SONG Ge;YU Zhi-peng;WEI Ling-ling;JIN Ju-ying;LI Wei-min(Department of Nutrition, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061;Department of Radiology, People s Hospital of Wuwei, Wuwei 733000;Danfeng County Hospital, Shangluo 726200, China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2019年第5期819-823,共5页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省社会发展科技攻关资助项目(No.2016SF-319)~~
