摘要
目的通过对5种不同种类的肝脏疾病和对照组进行血清透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)和Ⅳ型胶原(CⅣ)水平检测,探讨四项指标在肝脏疾病监测中的临床应用价值。方法对慢性重型乙型病毒肝炎患者82例,自身免疫性肝炎患者69例,药物性肝炎患者35例,其他慢性肝炎患者38例,肝功能衰竭患者39例,健康正常对照组61例进行肝纤四项指标的检测,比较各组肝纤四项的水平。同时测定肝病常用指标:胆汁酸、总胆红素(TB)、直接胆红素(DB)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(γ- GT)、白蛋白(ALB)、凝血酶原时间(PT)、纤维蛋白原(Fg)水平。分析肝纤四项与各项指标水平的相关性。结果慢性重型乙型病毒肝炎组、自身免疫性肝炎组、肝功能衰竭组四项指标水平均明显高于对照组,药物性肝炎组HA和PC-Ⅲ水平高于对照组,慢性重型乙型病毒肝炎组和肝功能衰竭组各项指标水平无差异,慢性重型乙型病毒肝炎组中肝纤四项指标水平与其他常用肝脏检测指标水平的相关性最为显著,肝功能衰竭组肝纤四项指标水平较为独立。结论肝纤四项指标与其他指标的联合监测能更好的反映发展性肝脏疾病发生发展的活跃情况,及对疾病治疗效果的全面评估。
Objective To investigate the clinical value of four indicators in five different kinds of liver diseases through the detection of serum levels of Hyaluronic acid(HA),Laminin(LN),Type Ⅲ procollagen( PC-Ⅲ),and type Ⅳ collagen(C Ⅳ)in the patient group and control group. Methods In the current study,the patient groups included 82 cases with chronic severe hepatitis B virus,69 cases of antoimmune hepatitis,35 cases of drug- induced hepatitis,38 cases of other chronic hepatitis,39 cases liver failure,while 61 cases were selected as the normal control group.All the cases were tested and compared with the levels of four liver fibrosis indicators,meanwhile,the bile acid,total bilirubin(TB),direct bilirubin(DB),glutamate aminotransferase(AST),glutamate lalnine aminotransferase(ALT),gamma- glutamyl transpeptipase(γ- GT),albumin(ALB),prothrombin time(PT),and fibrinogen(Fg)were also measured.The correlation between liver fibrosis items and the other index levels were analyzed. Results The four liver fibrosis items in the chronic severe hepatitis B virus group,autoimmune hepatitis group and liver failure group were significantly higher than that of the control group.The serum levels of HA and PC-Ⅲ in the drug- induced hepatitis were higher than that of the control group.There were no differences between the chronic severe hepatitis B virus and liver failure groups,but in the chronic severe hepatitis b virus group,the liver fibrosis indicators had the most significant correlation with other common liver indexes.The liver failure group had less correlation among these indicators. Conclusion The four indexes of hepatic fibrosis can reflect the activity of hepatic fibrosis and the progress of these diseases.The combined monitoring of these four markers with other indicators had a better performance for the evaluation of the clinical progress and comprehensive evaluation of treatment.
作者
封莉
张小英
杨玉婷
黄丽娜
陈婷婷
胥萍
FENG Li;ZHANG Xiao-ying;YANG Yu-ting;HUANG Li-na;CHEN Ting-ting;XU Ping(The Clinical Laboratory Center of Suzhou Fifith People’s Hospital,Suzhou 215007,China;Suzhou Laboratory of Infectionand Immunity,Suzhou 215007,China;The Infectious Disease of Suzhou Fifth People’s Hospital,Suzhou 215007,China)
出处
《标记免疫分析与临床》
CAS
2019年第8期1349-1353,共5页
Labeled Immunoassays and Clinical Medicine
