摘要
目的探讨羟苯磺酸钙联合复方α-酮酸片对糖尿病肾病疗效及炎症反应、肾功能的影响。方法选择2016年11月-2018年11月我院收治的70例糖尿病肾病患者,按随机数字表法分为2组各35例。对照组给予常规控制血糖治疗,观察组采取羟苯磺酸钙联合复方α-酮酸片治疗,比较2组临床疗效及炎症反应[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白介素-6(IL-6)]及肾功能[24 h尿微量蛋白(24 h UMA)、肌酐(SCr)、血尿素氮(BUN)]。结果治疗3个月后,观察组有效率高于对照组,TNF-α、CRP、IL-6、24 h UMA、SCr、BUN指标均较对照组低,差异有统计学意义(P<0.05)。结论糖尿病肾病给予羟苯磺酸钙联合复方α-酮酸片治疗效果显著,可改善患者炎症反应,提高肾功能。
Objective To study the effect of calcium dobesilate and compound α-ketoacid tablet on inflammatory response and renal function of diabetic nephropathy(DN). Methods 70 cases of DN from November2016 to November 2018 were divided into 2 groups by random number table, 35 cases in each group. Control group took blood glucose control therapy, observation group took calcium dobesilate and compound α-ketoacid tablet. Clinical efficacy, inflammatory response(TNF-α, CRP, IL-6), renal function(24 h UMA, Scr, BUN)were compared.Results After 3 m treatment, effective rate of observation group was higher than control group, while TNF-α, CRP, IL-6,24 h UMA, Scr, BUN were lower than control group(P<0.05). Conclusion Calcium dobesilate and compoundα-ketoacid tablet for DN are effective, it can improve inflammatory response and increase renal function.
作者
姚玲
吴文胜
王英霞
Yao Ling;Wu Wensheng;Wang Yingxia(The Fifth People's Hospital of Shangrao City,Shangrao,Jiangxi 334000)
出处
《基层医学论坛》
2019年第28期4002-4003,共2页
The Medical Forum
基金
上饶市科技计划任务(20184CKJ09)
关键词
糖尿病肾病
羟苯磺酸钙
复方Α-酮酸片
炎症反应
肾功能
Diabetic nephropathy
Calcium dobesilate
Compound α-ketoacid tablet
Inflammatory response
Renal function
