摘要
目的探讨肺癌患者抑郁症状的变化及其对生存期的影响,为肺癌患者的心理治疗提供依据。方法纳入2010年至2013年在本院诊断并治疗的肺癌患者339例,采用流行病学研究中心抑郁量表对患者的抑郁情况进行诊断,并每年进行随访。观察患者在生存期内抑郁症状的变化,并评估抑郁症状对患者生存率的影响。结果 339例肺癌患者中,133例(39%)患者在基线时有抑郁症状,另71例(21%)患者在治疗期间出现新发抑郁症状。在基线时,抑郁症状与死亡率增加相关(HR:1.19,95%CI:1.04~1.34)。观察期内从未有抑郁症状的患者135例,新发抑郁症状患者71例,抑郁症状缓解患者46例,持续抑郁症状患者87例,以从未有抑郁症状组作为参考组,新发抑郁症状的HR为1.36(95%CI:1.12~1.61);抑郁症状缓解患者的HR为1.11(95%CI:0.97~1.25),持续抑郁症状患者的HR为1.33(95%CI:1.09~1.57)。结论在肺癌患者中,抑郁症状的纵向变化与生存期相关。抑郁症状缓解者与从未有过抑郁症状者的死亡率相似,低于持续抑郁症状者和新发抑郁症状者的死亡率。
Objective To explore the changes of depression in patients with lung cancer and their impacts on the survival period,so to provide evidence for psychological treatment of patients with lung cancer.Methods 339 lung cancer patients diagnosed and treated in our hospital and other hospital from 2010 to 2013 were included.The depression status of patients was diagnosed by the Depression Scale of Epidemiological Research Center and followed up every year.To observe the changes of depressive symptoms during the survival period,and to evaluate the impact of depressive symptoms on the survival rate of patients.Results Among 339 participants,133 (39%) had depression symptoms at baseline and an additional 71 (21%) developed new-onset depression symptoms during treatment.At baseline,depression symptoms were associated with increased mortality (hazard ratio [HR],1.19,95% CI: 1.04-1.34).Participants were classified into the following four groups based on longitudinal changes in depression symptoms from baseline to follow-up: never depression symptoms (n=135),new-onset depression symptoms (n=71),depression symptom remission (n=46),and persistent depression symptoms (n=87).HRs were as follows: new-onset depression symptoms,1.36 (95% CI: 1.12-1.61),depression symptom remission,1.11 (95% CI: 0.97-1.25),and persistent depression symptoms,1.33 (95% CI: 1.09-1.57).Conclusions Among patients with lung cancer,longitudinal changes in depression symptoms are associated with differences in mortality.Symptom remission is associated with a similar mortality rate as never having had depression,which is lower than that in persistent and new-onset depression symptoms.
作者
朱州
倪秉强
陈日新
张志红
李竟长
张建
Zhu Zhou;Ni Bingqiang;Chen Rixin;Zhang Zhihong;Li Jingchang;Zhang Jian(Department of Oncology,Liuzhou General Hospital,Liuzhou 545006,China)
出处
《中国医师杂志》
CAS
2019年第8期1156-1159,共4页
Journal of Chinese Physician
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z2015136)~~
关键词
肺肿瘤
抑郁
存活率
Lung neoplasms
Depression
Survival rate
