摘要
目的探讨替莫唑胺治疗高级别胶质瘤细胞(HGG)中对巨噬细胞集落刺激因子(GM-CSF)水平的影响.方法选取2014年6月至2017年6月HGG术后患者100例,依据随机数字表法分为替莫组和常规组,每组各50例.常规组给予常规三维适形放疗治疗,替莫组在此基础上给予替莫唑胺治疗,比较两组GM-CSF水平、疗效及安全性.结果替莫组治疗1、3个月后GM-CSF水平明显高于常规组,差异有统计学意义(P<0.05);替莫组治疗有效率明显高于常规组,差异有统计学意义(P<0.05);替莫组和常规组不良反应率比较,差异无统计学意义(P>0.05);替莫组中位生存期、1年生存率明显高于常规组,差异有统计学意义(P<0.05).结论替莫唑胺治疗可有效改善HGG术后患者GM-CSF水平,有利于提高患者的疗效及生存预后,且具有良好的安全性,值得临床作进一步推广.
Objective To discuss the effect of temozolomide on macrophage colony stimulating factor(GM-CSF)level in high grade glioma cells(HGG). Methods 100 patients with after HGG operation were selected from June 2014 to June 2017 in our Hospital,according to the random distribution,all patients were divided into TiMo group(50 cases)and routine group(50 cases),routine group was treated with conventional three-dimensional conformal radiotherapy,TiMo group was treated with temozolomide on this basis. The two groups of GM-CSF levels,efficacy and safety were compared. Results After treatment for 1 and 3 months,the GM-CSF level of the TiMo group was significantly higher than that of the routine group,the difference was statistically significant(P<0.05).The effective rate of the TiMo group was significantly higher than that of the routine group,the difference was statistically significant(P<0.05).The rate of adverse reaction between the TiMo group and the routine group was compared,the difference was not statistically significant(P>0.05).The median survival time and the 1 year survival rate of the TiMo group were significantly higher than those of the routine group,the difference was statistically significant(P<0.05). Conclusion Temozolomide treatment can effectively improve GM-CSF level after HGG.It is beneficial to improve the curative effect and survival prognosis of patients,and has good safety,it's worth for further clinical promotion.
出处
《浙江临床医学》
2019年第8期1076-1078,共3页
Zhejiang Clinical Medical Journal
基金
浙江省衢州市科学计划项目(20172040).
