摘要
混合表型急性白血病(MPAL)是急性白血病(AL)的一种罕见类型,该病患者的白血病细胞可同时表达髓系、T/B细胞系的多种细胞系表型。目前,MPAL的诊断主要依据2016年世界卫生组织(WHO)发布的髓系肿瘤及白血病分类及诊断标准。MPAL的发病率低,与其他类型AL相比MPAL患者预后较差,疾病的治疗难度较大。对于MPAL的发病机制,目前尚无统一认识。近年随着生物技术的发展,相关研究者对MPAL的认识逐渐加深。笔者拟就MPAL的诊断、发病机制、治疗等方面的研究最新进展进行阐述。
Mixed phenotype acute leukemia (MPAL) is an uncommon subtype of acute leukemia (AL). It is characterized by the expression of multi-lineage immunophenotypic markers representing myeloid, T or B lymphoid lineage in leukemia cells. The diagnosis of MPAL refers to the World Health Organization (WHO) classification of myeloid neoplasms and AL proposed in 2016. Given the low prevalence and inferior prognosis of MPAL, it′s difficult to choose the optimal treatment for MPAL patients. Pathogenesis of MPAL remains largely unknown. Due to the development of biologic technology, researchers now have a better comprehension of this rare disease. This article reviews the advances of diagnosis, pathogenesis and treatment in MPAL.
作者
陈嘉媛
常英军
魏辉
Chen Jiayuan;Chang Yingjun;Wei Hui(Institution of Hematology and Blood Disease Hospital,Chinese Academy of Medical Sciences,Tianjin 300020,China;Peking University People′s Hospital & Peking University Institute of Hematology,National Clinical Research Center for Hematologic Disease,Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,China)
出处
《国际输血及血液学杂志》
CAS
2019年第4期283-288,共6页
International Journal of Blood Transfusion and Hematology
基金
国家自然科学基金(81670159)
中国医学科学院医学与健康科技创新工程(2016-I2M-3-004)
天津市自然科学基金(18JCZDJC45000).
关键词
白血病
双表型
急性
诊断
治疗
发病机制
Leukemia, biphenotypic, acute
Diagnosis
Therapy
Pathogenesis mechanisms
