摘要
目的探究经典名方当归补血汤防治糖尿病(DM)的药效物质基础和作用机制,以期为DM的中药防治提供更多选择。方法借助中药整合药理学平台(TCMIP),预测分析当归补血汤的作用机制和药效物质基础。结果当归补血汤中的50个“黄芪-当归”成分,通过直接或间接作用于60个关键药靶,这些药靶作用于神经-内分泌系统、细胞间连接、激素信号通路、心血管循环系统等30条主要调控通路,来纠正DM及其并发症的疾病失衡网络。黄芪中参与DM防治的主要为黄芪皂苷类、黄芪苷类、黄酮类等;当归中参与DM防治的主要为阿魏酸等有机酸、β-甜没药烯等油性成分、豆甾醇-β-D-葡萄糖苷、伞形花内酯、东莨菪素等。结论当归补血汤中的50个“黄芪-当归”成分,可能是通过精氨酸加压素受体(AVPR)的3个亚型AVPR1A、AVPR1B和AVPR2相关受体信号通路,来发挥防治DM的作用,且黄芪为关键成分。
Aim To explore the pharmacodynamic material basis and mechanism of the classic TCM excellent prescriptions(cTCMep) Danggui Buxue decoction, so as to provide more choices for the prevention and treatment of diabetes mellitus (DM). Methods With the integrative pharmacology of traditional Chinese medicine(TCMIP), we predicted the pharmacodynamic material basis and mechanisms of the cTCMep Danggui Buxue decoction for treatment of DM. Results The 50 “Astragalus-Angelica” components in the cTCMep Danggui Buxue decoction directly or indirectly acted on 60 key drug targets. These drug targets restored the disease imbalance network of DM and its complications by acting on 30 major regulatory pathways such as nervous-endocrine system, gap junction, hormone signaling pathways, and cardiovascular circulatory system. The main components of Astragalus membranaceus involved in the prevention and treatment of DM were astragalosides, astragalosides and alavonoids. The main components involved in the prevention and treatment of DM in Angelica sinensis were organic acids such as ferulic acid, oil components such as β-sweet myrrh, stigmasterol-β-D-glucoside, smbelliferol and scopolamine. Conclusions The 50 “Astragalus-Angelica” components in the cTCMep Danggui Buxue decoction may play a role in preventing and treating DM through the AVPR1A, AVPR1B and AVPR2 (AVPR: arginine vasopressin receptor, three subtypes), of which Astragalus membranaceu is the key component.
作者
张倩韬
侯敏娜
彭修娟
杜蓓
蔡洁
刘峰
ZHANG Qian-tao;HOU Min-na;PENG Xiu-juan;DU Bei;CAI Jie;LIU Feng(Medical College,Shaanxi Institute of International Trade & Commerce, Xi’an 712046;Academy of Chinese Materia Medica, Shaanxi Institute of International Trade & Commerce, Xi’an 712046,China;Shaanxi Buchang Pharmaceutical Company Ltd, Xi’an 710075,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第9期1314-1319,共6页
Chinese Pharmacological Bulletin
基金
国家科技部“重大新药创制”科技重大专项(No 2018ZX09721005-009-013)
生物医药创新制药技术研究院士专家工作站资助项目(陕科协发[2017]事企字15号)
陕西国际商贸学院中药质量标志物创新团队项目(No:SSY18TD02)
关键词
经典名方
当归补血汤
糖尿病
作用机制
药效物质基础
精氨酸加压素受体
classic TCM excellent prescriptions
Danggui Buxue decoction
diabetes mellitus
mechanism
pharmacodynamic material basis
arginine vasopressin receptor
