摘要
目的:探讨中药方剂对术后乳腺纤维瘤患者的临床疗效和对患者生命质量的影响。方法:选取2015年5月至2016年2月璧山区人民医院外科进行手术治疗的乳腺纤维瘤患者152例作为研究对象,按照随机数字表分为对照组和观察组,每组76例。对照组患者进行单纯的手术治疗。观察组患者进行手术治疗之后,采用医院中药方剂口服治疗3个月,并定期对2组患者进行随访,观察并记录随访过程中发生疾病复发患者的例数,采用放射免疫法检测患者术前以及术后3个月的雌激素水平、抑郁自评量表(SDS)和视觉模拟评分法(VAS)评分。结果:术后观察组和对照组患者雌激素水平、SDS和VAS评分均显著低于术前,差异有统计学意义(P<0.05)。对照组患者总复发58例,总复发率为76.32%,观察组总复发30例,总复发率为39.47%。观察组术后乳腺纤维瘤的复发率显著低于对照组,差异有统计学意义(P<0.05),且术后3个月,观察组患者的血清雌激素水平(二醇、雌三醇、孕酮和雌二醇/孕酮)、SDS和VAS评分均低于对照组,差异有统计学意义(P<0.05)。结论:中药方剂可以通过降低术后乳腺纤维瘤患者的血清雌二醇、雌三醇、孕酮和雌二醇/孕酮等雌激素的水平,降低术后患者的乳腺纤维瘤复发率,显著改善患者临床症状并提高生命质量。
Objective: To explore the clinical efficacy and quality of life of traditional Chinese medicine formula in patients with breast fibroma after operation. Methods: A total of 152 patients with breast fibroma who underwent surgical treatment in Chongqing Bishan District People′s Hospital from May 2015 to February 2016 were randomly divided into a control group and an observation group,with 76 patients in each group.The patients in the control group were treated with surgical resection of tumors,and the patients in the observation group were treated with oral administration of traditional Chinese medicine formula prepared by our hospital for 3 month after surgical resection of tumors.Patients in the 2 groups were followed up regularly and the postoperative recurrence rates,the levels of estrogen,scores of SDS and VAS were recorded and compared between the 2 groups. Results: The levels of estrogen,scores of SDS and VAS in the the 2 groups after operation were significantly lower than before operation( P <0.05).Totally 58 cases had recurrence in the control group,with the recurrence rate of 76.32%,while 30 cases in the observation group of 39.47% recurrence rate.The postoperative recurrence rate of breast fibroma in the observation group was significantly lower than that in the control group( P <0.05),and the levels of serum estradiol,estriol,progesterone and estradiol/progesterone,scores of SDS and VAS in the observation group were all lower than those in the control group after 3 months( P <0.05). Conclusion: The traditional Chinese medicine formula can reduce the recurrence rate of breast fibroma,the levels of estradiol,estriol,progesterone and estradiol/progesterone,and significantly improve the clinical symptoms of patients and increase the quality of life in patients with breast fibroma after operation,with high clinical application value.
作者
徐继刚
胡世珍
吕宝伟
邓大河
Xu Jigang;Hu Shizhen;Lyu Baowei;Deng Dahe(Department of Chest,Heart and Breast Surgery,Chongqing Bishan District People′s Hospital,Chongqing 402760,China;Department of Health Physical Examination,Southwest University Hospital,Chongqing 402760,China;Department of Traditional Chinese Medicine,Liaocheng People′s Hospital,Liaocheng 252000,China;Jiangnan ward,Department of General Medicine, Chongqing Three Gorges Central Hospital, Chongqing 404000,China)
出处
《世界中医药》
CAS
2019年第8期2125-2128,共4页
World Chinese Medicine
基金
山东省中医药科技发展计划项目(2015485)
关键词
中药方剂
乳腺纤维瘤
雌激素
临床疗效
生命质量
疼痛
复发率
临床价值
Traditional Chinese medicine formula
Fibroma of mammary gland
Estrogen
Clinical efficacy
Quality of life
Pain
Recurernce rate
Clinical value
