摘要
背景:氨甲环酸可减少膝关节置换术后出血,但目前国内外仍缺乏氨甲环酸对膝关节镜术后疼痛的相关报道。目的:探讨氨甲环酸静脉滴注联合关节腔注射给药对膝关节镜术后疼痛及早期恢复的影响。方法:重庆市人民医院2016年11月至2018年1月接受膝关节镜手术的105例半月板损伤患者纳入研究,随机分为关节腔注射组、联合组(静脉滴注联合关节腔注射组)及对照组。所有患者对治疗方案均知情同意,且得到医院伦理委员会批准。术后6,12,24,48,72h评估静息目测类比评分,术后1,3,5,7d评估活动目测类比评分;术后1,3,5,7d测量膝关节活动度;记录补救性地佐辛的使用例数及使用量;对比术前及术后末次随访时Lysholm膝关节功能评分。结果与结论:①关节腔注射组术后6,12,24h静息目测类比评分高于联合组(P<0.05),余时间点差异无显著性意义(P>0.05);②关节腔注射组术后1,3d活动目测类比评分高于联合组(P<0.05),余时间点差异无显著性意义(P>0.05);③联合组补救性地佐辛使用量少于关节腔注射组(P<0.05);关节腔注射组术后1,3,5,7d膝关节活动度小于联合组(P<0.05);④关节腔注射组与联合组间术后末次随访膝关节Lysholm评分差异无显著性意义(P>0.05);⑤结果表明,氨甲环酸静脉滴注联合关节腔注射给药更能有效缓解膝关节镜术后早期疼痛,促进术后早期膝关节功能恢复。
BACKGROUND: Tranexamic acid could reduce bleeding after knee joint replacement, but there is still lack of reports about tranexamic acid on pain after arthroscopy. OBJECTIVE: To investigate the effect of intravenous tranexamic acid infusion combined with articular cavity injection on pain and early rehabilitation after knee arthroscopy. METHODS: From November 2016 to January 2018, 105 patients with meniscus injury who underwent knee arthroscopy in Chongqing General Hospital were included. The patients were randomly divided into injection group(simple articular cavity injection gr oup), combined group(intravenous drip combined with articular cavity injection group) and control group. All patients signed the informed c onsent. This study was approved by the Hospital Ethics Committee. Visual analog scale score at rest was assessed at 6, 12, 24, 48, 72 hours postoperatively. Visual analog scale score at exercise was evaluated at 1, 3, 5, 7 days postoperatively. Range of motion of the knee was detec ted at 1, 3, 5, 7 days postoperatively. The number of use cases and dosage of remedial dizocine were recorded. Lysholm knee function score was compared before operation and during follow up after operation. RESULTS AND CONCLUSION:(1) Visual analog scale score at rest was significantly higher in the injection group than in the combined group at 6, 12, 24 hours postoperatively(P < 0.05). There was no statistical difference at the rest time points(P > 0.05).(2) Visual analog scale score at exercise was higher in the injection group than in the combined group at 1 and 3 days(P < 0.05). There was no statistical difference at the rest time points(P > 0.05).(3) The dosage of remedial dizocine was less in the combined group than in the injection group(P < 0.05). The range of motion of the knee was smaller in the injection group than in the combined grou p at 1, 3, 5, 7 days(P < 0.05).(4) There was no significant difference in Lysholm score between the injection group and the combined group in the last follow-up(P > 0.05).(5) Resul
作者
王海若
刘曦
李明晋
陈小华
梁婷
丁永清
唐小莉
王霁
马会旭
Wang Hairuo;Liu Xi;Li Mingjin;Chen Xiaohua;Liang Ting;Ding Yongqing;Tang Xiaoli;Wang Ji;Ma Huixu(Department of Orthopedics, Chongqing General Hospital, Chongqing 400021, China;Department of Radiology, Chongqing Hospital of Traditional ChineseMedicine, Chongqing 400022, China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第36期5766-5771,共6页
Chinese Journal of Tissue Engineering Research
基金
重庆市卫生和计划生育委员会医学科研计划项目(2017MSXM056)，项目负责人：王霁
重庆市渝中区科委基础与前沿研究计划项目(20150131)，项目负责人：马会旭
重庆市人民医院医学科技创新基金项目(Y2017MSXM08)，项目负责人：马会旭~~
