摘要
目的观察草酸艾司西酞普兰联合盐酸度洛西汀治疗抑郁症的临床效果.方法选择大同市第六人民医院2016年9月至2018年9月接受治疗的106例抑郁症患者作为观察对象,随机将其分为A组和B组,每组53例.A组患者采用草酸艾司西酞普兰联合盐酸度洛西汀进行治疗,B组患者单用盐酸度洛西汀进行治疗.比较A组和B组治疗后的有效率、汉密尔顿抑郁(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分以及不良反应发生率.结果治疗后5周,A组总有效率(96.23%)高于B组(81.13%,P<0.05).治疗前,A组HAMD、HAMA评分与B组比较,差异未见统计学意义(P>0.05);治疗后,A组各个时间段HAMD、HAMA评分均低于治疗前和B组(P均<0.05).治疗后5周,A组不良反应发生率(3.77%)高于B组(16.98%,P<0.05).结论采用草酸艾司西酞普兰联合盐酸度洛西汀治疗抑郁症患者,临床疗效显著,且其在改善抑郁和焦虑情况方面临床价值和安全性较高,因此推广价值较高.
Objective To observe the clinical efficacy of escitalopram oxalate combined with duloxetine hydrochloride in the treatment of depression.Methods A total of 106 depressive patients treated in the Sixth People’s Hospital of Datong from September 2016 to September 2018 were randomly divided into group A and group B,with 53 cases in each group.Patients in group A were treated with escitalopram oxalate combined with duloxetine hydrochloride,while patients in group B were treated with duloxetine hydrochloride alone.Effectiveness,Hamilton depression(HAMD)score,Hamilton anxiety scale(HAMA)score and incidence of adverse reactions after treatment were compared between group A and group B.Results After 5 weeks of treatment,the total effective rate of group A(96.23%)was higher than that of group B(81.13%,P<0.05).Before treatment,there was no significant difference in HAMD and HAMA scores between group A and group B(P>0.05);after treatment,HAMD and HAMA scores in group A were lower than those before treatment and group B(P<0.05).After 5 weeks of treatment,the incidence of adverse reactions in group A(3.77%)was higher than that in group B(16.98%,P<0.05).Conclusions Escitalopram oxalate combined with duloxetine hydrochloride in the treatment of depression patients,the clinical efficacy is significant,and its clinical value and safety in improving depression and anxiety is higher,so the promotion value is higher.
作者
张桂峰
李冬华
Zhang Guifeng;Li Donghua(Department of Psychiatry,the Sixth People's Hospital of Datong,Datong 037008,China;Psychological Examination Room,the Sixth People's Hospital of Datong,Datong 037008,China)
出处
《中国实用医刊》
2019年第14期95-98,共4页
Chinese Journal of Practical Medicine
