摘要
巨噬细胞来源于骨髓干细胞,是一种重要的固有免疫细胞,存在于所有组织中并且具有功能多样性,例如吞噬作用,抗原提呈作用等。巨噬细胞在监视和调节局部微环境中也发挥着重要作用。代谢重编程是细胞代谢发生异常的统称,包括代谢相关产物、酶、代谢途径等变化。而代谢的异常是导致局部微环境改变的主要因素。本文重点讨论代谢重编程对巨噬细胞的可塑性和功能的影响。
Macrophages are derived from bone marrow stem cells and are an important innate immune cell that is present in all tissues and has functional diversity,such as phagocytosis,antigen presentation,and so on.Macrophages also play an important role in monitoring and regulating the local microenvironment.Metabolic reprogramming is a general term for metabolic abnormalities,including metabolically related products,enzymes,and metabolic pathways.Metabolic abnormalities are the main factors leading to changes in the local microenvironment.This paper focuses on the effects of metabolic reprogramming on the plasticity and function of macrophages.
作者
杨雪
杨勇
YANG Xue;YANG Yong(Institute of Pharmaceutical Sciences,China Pharmaceutical University,Nanjing 211100,China)
出处
《药学研究》
CAS
2019年第8期481-485,共5页
Journal of Pharmaceutical Research
基金
国家青年科学基金项目(No.81703562)
关键词
巨噬细胞
炎症
葡萄糖/代谢
有氧糖酵解
Macrophage
Inflammation
Glucose/metabolism
Aerobic glycolysis
