摘要
目的探讨胱抑素C和同型半胱氨酸(Hcy)水平对哈萨克族原发性高血压(EH)老年患者肾功能损伤的诊断价值。方法前瞻性收集2015年1月~2018年2月参与新疆地区流行病学调查的哈萨克族EH患者128例,根据患者是否存在肾功能损伤分为肾功能损伤组40例和单纯高血压组88例。观察2组实验室指标和临床特征差异,采用ROC曲线分析各项指标诊断价值。结果与单纯高血压组比较,肾功能损伤组胱抑素C[(1.94±0.44)mg/L vs (1.24±0.36)mg/L,P=0.000]和Hcy水平增高[(21.43±6.82)μmol/L vs (13.95±4.21)μmol/L,P=0.000];胱抑素C和Hcy诊断哈萨克族EH患者肾功能损伤具有一定价值,两者曲线下面积分别为0.889(95%CI:0.825~0.953,P=0.000)和0.810(95%CI:0.723~0.896,P=0.000),最佳诊断界值分别为1.77 mg/L和18.50μmol/L。多因素分析显示,胱抑素C和Hcy是哈萨克族EH的老年患者肾功能损伤的危险因素(P<0.05,P<0.01)。结论胱抑素C和Hcy可以作为哈萨克族EH老年患者早期肾功能损伤的诊断指标。
Objective To study the role of cystatin C and Hcy in diagnosis of renal function impairment in Kazakh elderly primary hypertension patients.Methods One hundred and twenty-eight Kazakh elderly primary hypertension patients involved in the epidemiological survey of Xinjiang Uygur Autonomous Region from January 2015 to February 2018 were divided into renal function impairment group(n=40)and simple hypertension group(n=88).Their serum levels of cystatin C,Hcy were measured and their clinical characteristics were recorded and compared.The role of serum cystatin C and Hcy levels in diagnosis of renal function impairment was analyzed by ROC curve analysis.Results The serum cystatin C and Hcy levels were significantly higher in renal function impairment group than in simple hypertension group(1.94±0.44 vs 1.24±0.36 mg/L,P=0.000;21.43±6.82 vs 13.95±4.21μmol/L,P=0.000).The cystatin C and Hcy played a certain role in diagnosis of renal function impairment in Kazakh elderly primary hypertension patients.The area under the curve for cystatin C and Hcy was[0.889(95%CI:0.825-0.953),P=0.000]and[0.810(95%CI:0.723-0.896),P=0.000]respectively.The best diagnostic threshold of cystatin C and Hcy was 1.77 mg/L and 18.50μmol/L respectively.The cystatin C and Hcy were the risk factors for renal function impairment in Kazakh elderly primary hypertension patients(P<0.05,P<0.01).Conclusion Cystatin C and Hcy play a role in diagnosis of renal function impairment in Kazakh elderly primary hypertension patients.
作者
李永陟
王忠
单微微
黄辉
Li Yongzhi;Wang Zhong;Shan Weiwei;Huang Hui(Department of Internal Medicine,Shihezi University Medical College,Shihezi 832000,Xinjiang Uygur Autonomous Region,Chian)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2019年第8期818-821,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
国家自然科学基金(81460075)
