摘要
The development of pharmaceutical analytical methods represents one of the most significant aspects of drug development. Recent advances in microfabrication and microfluidics could provide new approaches for drug analysis, including drug screening, active testing and the study of metabolism. Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with various kinds of detection techniques are suitable for the high-throughput screening, detection and mechanistic study of drugs. This review highlights the latest (2010–2018) microfluidic technology for drug analysis and discusses the potential future development in this field.
The development of pharmaceutical analytical methods represents one of the most significant aspects of drug development.Recent advances in microfabrication and microfluidics could provide new approaches for drug analysis,including drug screening,active testing and the study of metabolism.Microfluidic chip technologies,such as lab-on-a-chip technology,three-dimensional(3 D)cell culture,organs-on-chip and droplet techniques,have all been developed rapidly.Microfluidic chips coupled with various kinds of detection techniques are suitable for the high-throughput screening,detection and mechanistic study of drugs.This review highlights the latest(2010-2018)microfluidic technology for drug analysis and discusses the potential future development in this field.
基金
financial support from the National Natural Science Foundation of China(No.81673398)
