摘要
肥胖是哮喘的主要危险因素之一,两者间关系的研究日益受到关注。肥胖可通过释放促炎症脂肪因子、引起代谢并发症等多种机制对哮喘产生重要影响。肥胖型哮喘是哮喘的特殊表型之一,患儿的临床症状更加严重,对激素治疗反应性低,有效的治疗方法尚不明确。因此现从病理生理机制、临床特点、肺功能和减重治疗等角度综述了近年来儿童时期肥胖型哮喘的研究进展,以加深对该疾病的了解,为其治疗提供参考。
Obesity is one of the major risk factors of asthma and recently researchers also pay more attention to the relationship between asthma and obesity.Obesity induces proinflammatory factors released and metabolic abnormalities in body and therefore has a great influence on asthma.Obese asthma is regarded as a special phenotype of asthma.Obese asthmatic children tend to have more severe clinical symptoms and lower response to inhaled corticosteroids while the effective therapy of these patients remains unknown.Thus,this paper reviews the current research progress of pathophysiology,clinical features,lung function and weight-loss treatment of obese asthma in children in order to broaden our knowledge of this disease.Also it provides references for clinical practice.
作者
张翊
张维溪
Zhang Hong;Zhang Weixi(Department of Pediatric Allergy and Immunology,the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325000,China)
出处
《国际呼吸杂志》
2019年第16期1273-1276,共4页
International Journal of Respiration
基金
国家自然科学基金(81770030).
关键词
哮喘
呼吸功能试验
肥胖
治疗
肥胖型哮喘
Asthma
Respiratory function tests
Obesity
Therapeutics
Obese asthma
