摘要
目的观察支气管哮喘患儿急性发作期、缓解期外周血白介素-10(IL-10)的水平变化,以进一步研究IL-10与儿童支气管哮喘的关系。方法收集2009年11月至2011年12月在内蒙古科技大学包头医学院第一附属医院儿科住院治疗的支气管哮喘急性发作患儿100例,作为哮喘急性发作期;随机抽取53例患儿经治疗后哮喘症状缓解,作为哮喘缓解期,其中3例失访,有效随访50例;其中100例急性发作期哮喘患儿,随机抽取46例测定其IgE的含量。选取健康体检儿童30例,作为对照组。采用酶联免疫吸附法测定血清IL-10水平。结果急性期与对照组比较,IL-10降低,差异有显著性(P<0.05);缓解期与对照组比较,IL-10降低,差异有显著性(P<0.05);急性期与缓解期比较,IL-10降低,差异有显著性(P<0.05);急性期外周血IL-10含量与IgE呈显著相关(r=-0.673,P〈0.05〉。结论 IL-10参与儿童支气管哮喘的发病,IL-10含量的降低可能是儿童支气管哮喘发病的原因之一,预示IL-10将可能作为诊断儿童支气管哮喘的特异性指标之一。
Objective This research aimed to inwestigate the serum levels of IL-10 content and its therapeutic effection of glucocorticoids in children with Asthma.Methods IL-10 expression of 100 case of children with asthma(asthma group)and 30 healthy controls(control group) in peripheral blood were determined by ELISA.Results Content of IL-10 in the peripheral blood was significantly lower in asthma group than in control group(P<0.05),however,there were significant difference between asthma exacerbation and stable asthma group(P<0.05).Content of IL-10 in the peripheral blood was significantly correlated with the content of IgE in asthma exacerbation.Conclusions IL-10 participate in the pathogenesis of asthma and restrain IgE.
作者
王建超
朱华
宋冬梅
张爱平
WANG Jian - chao;ZHU hua;SONG Dong - mei;ZHANG Ai - ping(The People, s Hospital of the Inner Mongolia Autonomous Region , Hohhot 010017 China;Department of Pediatrics, Affiliated Hospital of Inner MongoliaMedical University, Hohhot 010050 China;Department of Pediatrics,The First Affiliated Hospital of Baotou Medical College, Baotou 014010 China)
出处
《内蒙古医学杂志》
2019年第8期912-914,共3页
Inner Mongolia Medical Journal
