摘要
目的:研究西咪替丁与干扰素联合补锌在小儿轮状病毒(RV)感染性腹泻中的应用效果.方法:将我院2017年1月至2018年1月收治的180例RV感染性腹泻患儿随机分为观察组(西咪替丁+干扰素+补锌,n=90)与对照组(西咪替丁+干扰素,n=90),观察两组治疗效果.结果:观察组大便恢复时间、脱水纠正时间及体温恢复时间均显著短于对照组(P<0.05);治疗3d后统计发现,观察组大便RV抗原转阴率显著高于对照组(P<0.05),治疗有效率显著优于对照组(P<0.05);治疗10d后统计发现,两组血锌水平均较治疗前显著上升(P<0.05),且观察组上升幅度显著大于对照组(P<0.05),观察组治疗后血锌水平显著高于对照组(P<0.05);电话随访3个月,观察组复发率为8.89%,对照组复发率为20.00%,两组复发率存在显著性差异(χ^2=4.23,P<0.05).结论:西咪替丁与干扰素联合补锌在小儿RV感染性腹泻中具有良好的应用价值,能在短时间内缓解患儿临床症状,促进RV抗原转阴,并提高治疗效果,降低后期复发率,值得临床推广.
Objective: To study the application effects of cimetidine and interferon combined with zinc supplement in the treatment of rotavirus infectious diarrhea in children. Methods: 180 children patients with rotavirus infectious diarrhea admitted to our hospital from January 2017 to January 2018 were randomly divided into observation group (cimetidine + interferon+zinc supplement, n=90) and control group (cimetidine+interferon, n=90). The treatment effects were observed in the two groups. Results:The stool recovery time, dehydration correction time and body temperature recovery time in observation group were significantly shorter than those in control group (P<0.05). After 3 d of treatment, the negative conversion rate of fecal rotavirus antigen in observation group was significantly higher than that in control group (P<0.05), and the effective rate of treatment was significantly better than that in control group (P<0.05). After 10 d of treatment, the blood zinc levels in the two groups were significantly higher than those before treatment (P<0.05), and the increase in observation group was significantly greater than that in control group (P<0.05), and the blood zinc level in observation group after treatment was significantly higher than that in control group (P<0.05). At 3 months of telephone follow-up, the recurrence rate was 8.89% in observation group and was 20.00% in control group, and there was a significant difference in the recurrence rate between the two groups (χ^2=4.23, P<0.05). Conclusions: Zinc supplementation with cimetidine and interferon has a good application value in children with RV infectious diarrhea. It can alleviate the clinical symptoms of children in a short time, promote the negative reaction of RV antigen, improve the treatment effect and reduce the recurrence rate in later period. It is worthy of clinical promotion.
作者
王导利
王茜
何阿玲
WANG Daoli;WANG Qian;HE Aling(Northwest Women's and Children's Hospital, Shaanxi Xi'an 710061, China)
出处
《河北医学》
CAS
2019年第8期1371-1374,共4页
Hebei Medicine
基金
陕西省卫生厅科研基金项目,(编号:2015JM120147)
关键词
小儿轮状病毒感染性腹泻
西咪替丁
干扰素
补锌
疗效对比
Rotavirus infectious diarrhea in children
Cimetidine
Interferon
Zinc supplement
Efficacy comparison
