摘要
目的了解重庆市永川区人乳头瘤病毒(HPV)感染率、亚型及年龄分布,分析HPV感染流行的现状,为区域性HPV疫苗的研发和本地区HPV感染的防治提供一定依据。方法采用聚合酶链式反应(PCR)和反向膜杂交技术对2015年9月至2017年5月在该院就诊且满足纳入要求的10889例患者进行HPV检测。结果重庆市永川区HPV阳性率为24.60%,高、低危型感染前3位分别是HPV52、16、53亚型与HPV81、43、42亚型。单一、二重、多重(三重及以上)感染率分别为71.89%、18.96%、9.15%,其中二重感染以HPV52合并其他亚型最常见。HPV感染以40~<50岁感染率最高,感染率曲线整体呈倒“U”形,各年龄段HPV感染率差异有统计学意义(P<0.05)。结论重庆市永川区HPV的感染率、亚型及年龄分布较该地区以往研究有所变化,揭示了该地区HPV感染的现状及流行趋势,为区域性HPV疫苗的研发和该地区HPV的防治提供了切实依据。
Objective To investigate the infection rate,subtypes and age distribution of human papillomavirus(HPV)in Yongchuan District of Chongqing,and to analyze the epidemic status of HPV infection,so as to provide a basis for the development of regional HPV vaccine and the prevention and treatment of HPV infection in this area.Methods HPV was detected by polymerase chain reaction(PCR)and reverse membrane hybridization in 10 889 patients who met the inclusion requirements from September 2015 to May 2017.Results The positive rate of HPV in Yongchuan District of Chongqing was 24.60%.The top three high-risk and low-risk infections were HPV52,16,53 and HPV81,43 and 42.The single,double and multiple(triple and above)infections rate were 71.89%,18.96%and 9.15%respectively,of which HPV52 combined with other subtypes was the most common,and the infection rate of HPV was the highest in 40-<50 years old.The overall line was inverted“U”shape,and there was significant difference in HPV infection rate among different age groups(P<0.05).Conclusion The infection rate,subtype and age distribution of HPV in Yongchuan District of Chongqing have changed compared with previous studies in this area,revealing the current situation and epidemic trend of HPV infection in this area,and providing a practical basis for the development of regional HPV vaccine and the prevention and treatment of HPV in this area.
作者
彭书生
王科
袁永强
PENG Shusheng;WANG Ke;YUAN Yongqiang(Department of Clinical Laboratory,Yongchuan Hospital Affiliated to Chongqing Medical University,Chongqing 402160,China)
出处
《国际检验医学杂志》
CAS
2019年第16期1925-1928,共4页
International Journal of Laboratory Medicine
基金
国家高技术研究发展计划(863计划)(2011AA02A111)
