摘要
β样淀粉蛋白(Aβ)和tau蛋白在阿尔茨海默病(AD)发病过程中发挥重要作用,其代谢受到自噬的影响。AD发病早期,Aβ和tau蛋白的产生可经雷帕霉素靶标依赖性和非依赖性途径诱导自噬促进其清除。与AD相关的转录因子EB、载脂蛋白E4等也可调节自噬参与Aβ和tau蛋白代谢,影响AD病程。本文围绕近年来自噬在Aβ和tau蛋白代谢中的作用及与AD密切相关的自噬调节因子在AD发病机制中的作用综述如下。
Alzheimer's disease (AD) is characterized by β-amyloid (Aβ) deposition and tauprotein hyperphosphorylation, whereas its pathogenesis has not been fully known so far. The metabolism of Aβ and tau protein is critically affected by autophagy. In the early phase of AD, Aβ and tau protein can induce themselves to be eliminated via mTOR-dependent and independent autophagy pathways. In addition, transcription factors EB and apolipoprotein E4 also regulate autophagy and thus participate in the metabolism of Aβ and tau protein, affecting AD progression. This review summarized the roles of autophagy in the metabolism of Aβ and tau protein and the autophagy regulators closely related to AD in the recent studies.
作者
况煌
田慧珍
谭成勇
刘立华
洪芬芳
杨树龙
Kuang Huang;Tian Huizhen;Tan Chengyong;Liu Lihua;Hong Fenfang;Yang Shulong(Department of Physiology, School of Medicine, Nanchang University, Nanchang 330006, China;Department of Experimental Teaching Center, Nanchang University, Nanchang 330031, China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2019年第8期842-846,共5页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81660151、81660751)
江西省自然科学基金(20171BAB205085).
